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WSU-DLCL2Homo sapiens (Human)Cancer cell line

Also known as: WSUDLCL2, WSU-DLCL(2), WSU-DLCL-2, WSU-DCL2

🤖 AI SummaryBased on 10 publications

Quick Overview

Human B-cell lymphoma cell line for cancer research

Detailed Summary

WSU-DLCL2 is a human B-cell lymphoma cell line derived from diffuse large B-cell lymphoma (DLBCL). It is used in research to study the molecular mechanisms of lymphoma, including genetic mutations, gene expression, and drug sensitivity. This cell line is part of the Cancer Cell Line Encyclopedia (CCLE) and has been characterized for its genomic and transcriptomic features. It is valuable for investigating the role of specific genes and pathways in lymphoma progression and for developing targeted therapies.

Research Applications

Molecular mechanisms of lymphomaGenetic mutations and gene expression analysisDrug sensitivity studiesTargeted therapy development

Key Characteristics

Part of the Cancer Cell Line Encyclopedia (CCLE)Characterized for genomic and transcriptomic featuresUsed in studies of lymphoma progression

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1902
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age	41
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Diffuse large B-cell lymphoma
Lineage	Lymphoid
Subtype	Diffuse Large B-Cell Lymphoma, NOS
OncoTree Code	DLBCLNOS

DepMap Information

Source Type	DSMZ
Source ID	ACH-000534_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg248Gln (c.743G>A)	Unspecified	Somatic mutation acquired during proliferation	PubMed=20575032
MutationSimple	EZH2	p.Tyr646Phe (c.1937A>T) (Y641F)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11

D13S317

11,14

D16S539

10,13

D18S51

15,16

D19S433

12

D21S11

29,32.2

D2S1338

22,25

D3S1358

14,16

D5S818

11,12

D7S820

10,12

D8S1179

12,13

FGA

22

Penta D

10,13

Penta E

14,19

TH01

8,9

TPOX

8

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.

Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.

Leuk. Lymphoma 57:1015-1020(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.

O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.

J. Virol. 89:713-729(2015).

Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing.

Marra M.A.

Blood 122:1256-1265(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.

Mori F., Ding J.-M., Komatsu H., Iida S., Ueda R.

Int. J. Cancer 125:212-221(2009).

Bryostatin 1 down-regulates mdr1 and potentiates vincristine cytotoxicity in diffuse large cell lymphoma xenografts.

Mohamed A.N., Chelladurai B., Mohammad R.M.

Clin. Cancer Res. 4:1305-1314(1998).

Web Resources

bioivt.com tcpaportal.org