WSU-FSCCLHomo sapiens (Human)Cancer cell line
Also known as: WSUFSCCL
🤖 AI SummaryBased on 4 publications
Quick Overview
Human B-cell lymphoma cell line with t(14;18) and t(8;11) translocations
Detailed Summary
WSU-FSCCL is a human B-cell lymphoma cell line established from a patient with low-grade follicular small cleaved cell lymphoma in leukemic phase. It exhibits two chromosomal translocations, t(14;18)(q2;q21) and t(8;11)(q24;q21), along with other abnormalities such as 6q-, 1p+, and + (iq). The cell line expresses cytoplasmic and cell surface IgM-k and reacts with B-cell antigens. It is negative for T-cell and myeloid/monocyte antigens as well as Epstein-Barr virus nuclear antigen (EBNA). The cell line has a doubling time of ~26 hours and grows as a single-cell suspension. It provides a valuable model for studying the genetic and molecular mechanisms of lymphoma, particularly the role of bcl-2 and c-myc rearrangements in disease progression.
Research Applications
Study of chromosomal translocations in lymphomaInvestigation of bcl-2 and c-myc gene rearrangementsAnalysis of lymphoma cell proliferation and drug resistance
Key Characteristics
Expresses IgM-kPositive for B-cell antigensNegative for T-cell and myeloid antigensCarries t(14;18) and t(8;11) translocations
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1903 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age | 37 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Follicular lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Follicular Lymphoma |
| OncoTree Code | FL |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001708_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
12
D13S317
11,13
D16S539
11,13
D18S51
13,14
D19S433
14
D21S11
30
D2S1338
23,24
D3S1358
15,16
D5S818
12
D7S820
10,13
D8S1179
12,14
FGA
22,24
Penta D
9,13
Penta E
7,12
TH01
9.3
TPOX
11
vWA
18,20
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
A unique EBV-negative low-grade lymphoma line (WSU-FSCCL) exhibiting both t(14;18) and t(8;11).
Mohammad R.M., Mohamed A.N., Smith M.R., Jawadi N.S., Al-Katib A.
Cancer Genet. Cytogenet. 70:62-67(1993).
The leukemia-lymphoma cell line factsbook.";
Drexler H.G.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).