BC-3CHomo sapiens (Human)Cancer cell line
Also known as: BC3c
🤖 AI SummaryBased on 6 publications
Quick Overview
Human bladder cancer cell line with unique genetic and molecular characteristics.
Detailed Summary
BC-3C is a human bladder cancer cell line established from an invasive transitional cell carcinoma of the bladder in an 82-year-old female. It exhibits epithelial characteristics, including expression of cytokeratins 8 and 19, and lacks mesenchymal markers. The cell line shows a near-triploid karyotype with multiple chromosomal abnormalities. BC-3C cells demonstrate autocrine growth and express the epidermal growth factor receptor (EGFR), which is inhibited by EGF. This cell line is valuable for studying bladder cancer biology and therapeutic responses.
Research Applications
In vitro modeling of bladder cancerEGFR signaling studiesAutocrine growth mechanismsGenomic and karyotypic analysis
Key Characteristics
Epithelial origin with cytokeratin expressionNear-triploid karyotype with chromosomal anomaliesAutocrine growth capabilityEGFR expression and EGF inhibition
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1958 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Urinary bladder[UBERON:UBERON_0001255] |
Donor Information
| Age | 82 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Race | caucasian |
Disease Information
| Disease | Bladder carcinoma |
|---|---|
| Lineage | Bladder/Urinary Tract |
| Subtype | Bladder Urothelial Carcinoma |
| OncoTree Code | BLCA |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000593_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
9
D16S539
11,13
D18S51
14,21
D19S433
14,15
D21S11
29,32.2
D2S1338
17,25
D3S1358
17
D5S818
11,13
D7S820
11
D8S1179
14,15
FGA
19,25
Penta D
13,14
Penta E
12,13
TH01
6,9
TPOX
8
vWA
15,16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Bladder Cancer 4:169-183(2018).
Identification of mutations in distinct regions of p85 alpha in urothelial cancer.
Knowles M.A.
PLoS ONE 8:E84411-E84411(2013).
Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine.
Hurst C.D., Platt F.M., Knowles M.A.
Eur. Urol. 65:367-369(2014).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).