BL-2Homo sapiens (Human)Cancer cell line
Also known as: IARC BL 2, IARC-BL-2, IARC BL2, IARC-BL2, IARC/BL 02, IARC/BL2, BL 002, BL02, BL 02, BL 2, BL2
Quick Overview
BL-2 is a human B-cell lymphoma cell line derived from Burkitt's lymphoma, known for its specific chromosomal translocations an...
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1966 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone marrow[UBERON:UBERON_0002371] |
Donor Information
| Age | 7 |
|---|---|
| Age Category | Pediatric |
| Sex | Male |
Disease Information
| Disease | Burkitt lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Burkitt Lymphoma |
| OncoTree Code | BL |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001449_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene fusion | IGL | MYC-IGL | - | - | PubMed=7519050 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
OncoImmunology 3:e954893.1-e954893.12(2014).
Comprehensive cytogenetic and molecular cytogenetic analysis of 44 Burkitt lymphoma cell lines: secondary chromosomal changes characterization, karyotypic evolution, and comparison with primary samples.
Vettorazzi E., Bokemeyer C., Dierlamm J.
Genes Chromosomes Cancer 53:497-515(2014).
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.
Waldmann T.A., Rowe M., Mbulaiteye S.M., Rickinson A.B., Staudt L.M.
Nature 490:116-120(2012).
Genome-wide search for loss of heterozygosity in Burkitt lymphoma cell lines.
Eisinger F., Longy M., Romeo G., Lenoir G.M., Birnbaum D.
Genes Chromosomes Cancer 33:217-224(2002).
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.
Blood 91:1680-1687(1998).
VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection.
Chapman C.J., Zhou J.X., Gregory C.D., Rickinson A.B., Stevenson F.K.
Blood 88:3562-3568(1996).
Cytogenetic studies on Burkitt's lymphoma cell lines.";
Bernheim A., Berger R., Lenoir G.M.
Cancer Genet. Cytogenet. 8:223-229(1983).
Correlation between immunoglobulin light chain expression and variant translocation in Burkitt's lymphoma.
Lenoir G.M., Preud'homme J.-L., Bernheim A., Berger R.
Nature 298:474-476(1982).
Distinct reactivity of Burkitt's lymphoma cell lines with eight monoclonal antibodies correlated with the ethnic origin.
Lenoir G.M.
J. Natl. Cancer Inst. 73:841-847(1984).
The use of lymphomatous and lymphoblastoid cell lines in the study of Burkitt's lymphoma.
Lenoir G.M., Vuillaume M., Bonnardel C.
IARC Sci. Publ. 60:309-318(1985).
Immunophenotypic classification of 28 Burkitt cell lines with monoclonal antibodies and reagent selection for bone-marrow purging.
Dore J.-F., Lenoir G.M.
IARC Sci. Publ. 60:447-452(1985).
Expression of B-cell-specific markers in different Burkitt lymphoma subgroups.
Ehlin-Henriksson B., Manneborg-Sandlund A., Klein G.
Int. J. Cancer 39:211-218(1987).
Aberrant c-myc RNAs of Burkitt's lymphoma cells have longer half-lives.
Kofler E., Wiest S., Lenoir G.M., Bornkamm G.-W.
EMBO J. 4:3717-3725(1985).
Clustered somatic mutations in and around first exon of non-rearranged c-myc in Burkitt lymphoma with t(8;22) translocation.
Kaplan J.-C.
Nucleic Acids Res. 15:4553-4565(1987).
B-cell maturation stages of Burkitt's lymphoma cell lines according to Epstein-Barr virus status and type of chromosome translocation.
Manel A.-M., Vincent C., Bryon P.-A.
J. Natl. Cancer Inst. 78:235-242(1987).
Epstein-Barr virus (EBV) induces expression of B-cell activation markers on in vitro infection of EBV-negative B-lymphoma cells.
Lenoir G.M.
Proc. Natl. Acad. Sci. U.S.A. 84:8060-8064(1987).
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.
Newcomb E.W., Magrath I.T., Knowles D.M., Dalla-Favera R.
Proc. Natl. Acad. Sci. U.S.A. 88:5413-5417(1991).
p53 is frequently mutated in Burkitt's lymphoma cell lines.";
Farrell P.J., Allan G.J., Shanahan F., Vousden K.H., Crook T.
EMBO J. 10:2879-2887(1991).