BLUE-1Homo sapiens (Human)Cancer cell line
Also known as: Blue1, BLUE1
🤖 AI SummaryBased on 3 publications
Quick Overview
BLUE-1 is a human B-cell lymphoma cell line derived from a sporadic Burkitt lymphoma patient, characterized by unique chromosom...
Detailed Summary
BLUE-1 is a human B-cell lymphoma cell line established from a relapsed sporadic Burkitt lymphoma patient. It carries the typical t(8;14)(q24;q32) translocation involving the MYC and IGH genes, along with a novel t(6;20)(q15;q11.2) rearrangement. This cell line is EBV-negative and exhibits a unique cytogenetic profile, making it a valuable tool for studying the molecular mechanisms of B-cell malignancies. Its growth characteristics and genetic features support its use in research on lymphoma genetics, drug sensitivity, and therapeutic target identification.
Research Applications
Lymphoma researchMolecular genetics of B-cell malignanciesDrug sensitivity and therapeutic target identification
Key Characteristics
EBV-negativeCarries t(8;14)(q24;q32) translocationUnique t(6;20)(q15;q11.2) rearrangementHigh proliferative capacity in culture
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1967 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone marrow[UBERON:UBERON_0002371] |
Donor Information
| Age | 29 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Burkitt lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Burkitt Lymphoma |
| OncoTree Code | BL |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001450_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg273His (c.818G>A) | Homozygous | - | Unknown, PubMed=16264262 |
| Gene fusion | IGH | MYC-IGH | - | - | PubMed=31160637 |
| Gene fusion | BACH2 | BACH2-BCL2L1 | - | - | Unknown, PubMed=21412927 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
12
D13S317
11,13
D16S539
12
D18S51
15,16
D19S433
13
D21S11
28,32.2
D2S1338
14,16
D3S1358
18
D5S818
9,10
D7S820
7,10
D8S1179
14,16
FGA
21,24
Penta D
9,11
Penta E
12,13
TH01
6,9.3
TPOX
9,11
vWA
14,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Comprehensive cytogenetic and molecular cytogenetic analysis of 44 Burkitt lymphoma cell lines: secondary chromosomal changes characterization, karyotypic evolution, and comparison with primary samples.
Vettorazzi E., Bokemeyer C., Dierlamm J.
Genes Chromosomes Cancer 53:497-515(2014).
A BACH2-BCL2L1 fusion gene resulting from a t(6;20)(q15;q11.2) chromosomal translocation in the lymphoma cell line BLUE-1.
Burmeister T.
Genes Chromosomes Cancer 50:389-396(2011).