CL-11Homo sapiens (Human)Cancer cell line

Also known as: CL11

🤖 AI SummaryBased on 10 publications

Quick Overview

CL-11 is a human colorectal cancer cell line used in cancer research.

Detailed Summary

CL-11 is a human colorectal cancer cell line derived from a primary tumor. It is utilized in research to study the molecular mechanisms of colorectal cancer and to develop targeted therapies. The cell line has been characterized for its genetic and molecular features, including mutations and gene expression profiles. It is part of a collection of cell lines used to understand the heterogeneity of colorectal cancer and to identify potential therapeutic targets. CL-11 is also used to investigate the effects of various treatments on cancer cell growth and survival.
Generated on 6/17/2025

Basic Information

Database IDCVCL_1978
SpeciesHomo sapiens (Human)
Tissue SourceColon[UBERON:UBERON_0001155]

Donor Information

Age CategoryUnknown
SexMale

Disease Information

DiseaseColon adenocarcinoma
LineageBowel
SubtypeColon Adenocarcinoma
OncoTree CodeCOAD

DepMap Information

Source TypeDSMZ
Source IDACH-000249_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Ser215Asn (c.644G>A)Homozygous-from parent cell line SNU-668
MutationSimpleKRASp.Gln61His (c.183A>C)Heterozygous1 of 3 allelesUnknown, PubMed=8426738
MutationSimpleKRASp.Val14Ile (c.40G>A)Heterozygous-Unknown, Unknown
MutationSimpleFBXW7p.Arg479Gln (c.1436G>A)Heterozygous-Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
11
D13S317
13,14
D16S539
11,13
D18S51
14
D19S433
14
D21S11
31,32.2
D2S1338
17,19
D3S1358
15,16
D5S818
12
D7S820
9
D8S1179
14
FGA
22,23
Penta D
9,13
Penta E
10,11
TH01
6,9
TPOX
8
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Differential effector engagement by oncogenic KRAS.";

McCormick F.

Cell Rep. 22:1889-1902(2018).

Genomic determinants of protein abundance variation in colorectal cancer cells.

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.

Cell Rep. 20:2201-2214(2017).

Multi-omics of 34 colorectal cancer cell lines -- a resource for biomedical studies.

Myklebost O., Skotheim R.I., Sveen A., Lothe R.A.

Mol. Cancer 16:116.1-116.16(2017).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.

Nat. Commun. 6:7002.1-7002.10(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Growing colorectal tumors: minimizing microbial and stromal competition and assessing in vitro selection pressures.

Farrell T.M., Pettengill O.S., Longnecker D.S., Cate C.C., Cohn K.H.

Cytotechnology 34:205-211(2000).

Web Resources