CL-14Homo sapiens (Human)Cancer cell line

Also known as: CL14

🤖 AI SummaryBased on 7 publications

Quick Overview

CL-14 is a human cancer cell line used in research for studying colorectal cancer.

Detailed Summary

CL-14 is a human cancer cell line derived from colorectal tissue, utilized in various research applications including the study of molecular mechanisms in colorectal cancer. It is part of a comprehensive collection of cell lines used to understand the genetic and transcriptional diversity of tumors. CL-14 has been characterized for its ability to grow in vitro and is used in studies related to drug sensitivity and resistance. The cell line is part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in research to identify potential therapeutic targets and to understand the genetic basis of cancer progression. CL-14 has been used in studies involving the analysis of gene expression, mutation profiles, and their implications on drug response. It is also used to study the effects of various treatments on cancer cells, contributing to the development of targeted therapies.

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1979
Species	Homo sapiens (Human)
Tissue Source	Colon, sigmoid[UBERON:UBERON_0001159]

Donor Information

Age Category	Unknown
Sex	Male

Disease Information

Disease	Colon adenocarcinoma
Lineage	Bowel
Subtype	Colon Adenocarcinoma
OncoTree Code	COAD

DepMap Information

Source Type	DSMZ
Source ID	ACH-000342_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg273Cys (c.817C>T)	Homozygous	-	PubMed=35933914

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

8,12

D16S539

11,13

D18S51

D19S433

13,17

D21S11

28,29

D2S1338

21,25

D3S1358

D5S818

D7S820

11,12

D8S1179

FGA

Penta D

Penta E

10,12

TH01

6,8

TPOX

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies.

Safranko Z.M., Kurolt I.-C., Markotic A., Cicin-Sain L., Steenpass L.

PLoS ONE 16:E0255622-E0255622(2021).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.

Nat. Commun. 6:7002.1-7002.10(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Growing colorectal tumors: minimizing microbial and stromal competition and assessing in vitro selection pressures.

Farrell T.M., Pettengill O.S., Longnecker D.S., Cate C.C., Cohn K.H.

Cytotechnology 34:205-211(2000).

DOI PubMed PMC

Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus.

Hofmann W.-K., Bauer G., Michaelis M., Rabenau H.F., Doerr H.-W.

Cell. Mol. Life Sci. 61:2100-2112(2004).

DOI PubMed PMC

Web Resources

tcpaportal.org