CL-40Homo sapiens (Human)Cancer cell line

Also known as: CL40

🤖 AI SummaryBased on 9 publications

Quick Overview

Human colorectal cancer cell line for cancer research.

Detailed Summary

CL-40 is a human colorectal cancer cell line derived from a primary tumor. It is used in research to study molecular mechanisms and drug responses in colorectal cancer. The cell line has been characterized for its genetic and molecular profiles, including mutations and gene expression patterns. It is part of a comprehensive collection of cell lines used to understand cancer biology and develop targeted therapies.
Generated on 6/17/2025

Basic Information

Database IDCVCL_1982
SpeciesHomo sapiens (Human)
Tissue SourceColon[UBERON:UBERON_0001155]

Donor Information

Age CategoryUnknown
SexFemale

Disease Information

DiseaseColon adenocarcinoma
LineageBowel
SubtypeColon Adenocarcinoma
OncoTree CodeCOAD

DepMap Information

Source TypeDSMZ
Source IDACH-000798_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Arg248Gln (c.743G>A)UnspecifiedSomatic mutation acquired during proliferationPubMed=20575032
MutationSimpleTMPRSS2p.Val197Met (c.589G>A) (p.Val160Met, c.478G>A)Homozygous-PubMed=34339474
MutationSimpleTMPRSS2p.Gly8Val (c.23G>T) (c.-57+99G>T)Heterozygous-PubMed=34339474
MutationSimpleKRASp.Gly12Asp (c.35G>A)Unspecified-PubMed=29786757

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
10,12
D13S317
8,11
D16S539
11,12
D18S51
14
D19S433
12,13
D21S11
30,32.2
D2S1338
19,25
D3S1358
16
D5S818
11
D7S820
8,9
D8S1179
12,14
FGA
21,24
Penta D
10
Penta E
14
TH01
6,9
TPOX
8,9
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies.

Safranko Z.M., Kurolt I.-C., Markotic A., Cicin-Sain L., Steenpass L.

PLoS ONE 16:E0255622-E0255622(2021).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Genomic determinants of protein abundance variation in colorectal cancer cells.

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.

Cell Rep. 20:2201-2214(2017).

Multi-omics of 34 colorectal cancer cell lines -- a resource for biomedical studies.

Myklebost O., Skotheim R.I., Sveen A., Lothe R.A.

Mol. Cancer 16:116.1-116.16(2017).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.

Nat. Commun. 6:7002.1-7002.10(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Growing colorectal tumors: minimizing microbial and stromal competition and assessing in vitro selection pressures.

Farrell T.M., Pettengill O.S., Longnecker D.S., Cate C.C., Cohn K.H.

Cytotechnology 34:205-211(2000).

Web Resources