COLO 783Homo sapiens (Human)Cancer cell line

Also known as: Colorado 783, COLO783, Colo783, COLO #783, COLO-783

🤖 AI SummaryBased on 6 publications

Quick Overview

Human cancer cell line for research on tumor biology and drug sensitivity.

Detailed Summary

COLO 783 is a human cancer cell line derived from a tumor, widely used in cancer research. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been characterized for its genetic and molecular profiles. This cell line is utilized in studies related to cancer genomics, drug response, and molecular mechanisms of tumorigenesis. Its applications include investigating gene expression, mutations, and therapeutic targets, contributing to the development of personalized cancer treatments.

Research Applications

Cancer genomicsDrug response profilingMolecular mechanisms of tumorigenesisPersonalized cancer treatment development

Key Characteristics

Part of the Cancer Cell Line Encyclopedia (CCLE)Characterized for genetic and molecular profilesUsed in studies of gene expression and mutations

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1997
Species	Homo sapiens (Human)
Tissue Source	Right axillary lymph node[UBERON:UBERON_0001097]

Donor Information

Age	48
Age Category	Adult
Sex	Female

Disease Information

Disease	Melanoma
Lineage	Skin
Subtype	Melanoma
OncoTree Code	MEL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000812_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Pro27Leu (c.80C>T)	Homozygous	-	Unknown, Unknown
MutationSimple	TERT	c.1-146C>T (c.250C>T) (C250T)	Unspecified	In promoter	PubMed=31068700
MutationSimple	CDKN2A	p.Pro48Leu (c.143C>T)	Unspecified	-	PubMed=17260012
MutationSimple	CDKN1B	p.Glu14fs*109 (c.39_43delGGAGC)	Heterozygous	-	Unknown, Unknown
MutationSimple	BRAF	p.Val600Glu (c.1799T>A)	Unspecified	-	PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

11,12

D16S539

D18S51

13,14

D19S433

13,14

D21S11

30,33.2

D2S1338

17,25

D3S1358

D5S818

D7S820

D8S1179

13,15

FGA

20,21

Penta D

13,15

Penta E

TH01

7,9.3

TPOX

9,11

vWA

18,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Immunocytochemical analysis of cell lines derived from solid tumors.

Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.

J. Histochem. Cytochem. 49:1369-1378(2001).

DOI PubMed