Onda 9Homo sapiens (Human)Cancer cell line
Also known as: Case 10, no.9, ONDA9, Onda-9
🤖 AI SummaryBased on 4 publications
Quick Overview
Human glioma cell line with MMAC1/PTEN mutations and p16/p53 alterations.
Detailed Summary
Onda 9 is a human glioma cell line derived from an anaplastic glioma, characterized by specific genetic alterations. It exhibits mutations in the MMAC1 (PTEN) gene, including rare 3-bp deletions and a missense mutation, which are associated with tumor suppressor dysfunction. Additionally, Onda 9 shows abnormalities in the p16 and p53 tumor suppressor genes, contributing to its role in glioma research. These genetic features make it a valuable model for studying molecular mechanisms in glioma progression and therapeutic responses.
Research Applications
Analysis of MMAC1/PTEN gene mutations in gliomasStudy of p16 and p53 gene alterations in glioma progressionInvestigation of tumor suppressor gene dysfunction in glioma cell lines
Key Characteristics
MMAC1 (PTEN) gene mutations including 3-bp deletions and missense mutationsp16 gene deletions and mutationsp53 gene alterations with potential functional inactivation
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_1R14 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Brain, left temporal lobe[UBERON:UBERON_0002808] |
Donor Information
| Age | 58 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Glioblastoma |
|---|---|
| Lineage | CNS/Brain |
| Subtype | Glioblastoma |
| OncoTree Code | GB |
DepMap Information
| Source Type | JCRB |
|---|---|
| Source ID | ACH-001624_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | PTEN | p.Ile101del (c.301_303delATC) | Unspecified | - | from parent cell line Onda 9R |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,12
D13S317
11
D16S539
11,13
D18S51
13,15
D21S11
32.2
D3S1358
15
D5S818
9,12
D7S820
12
D8S1179
10
FGA
20,21,22
Penta D
9,13
Penta E
5,12
TH01
9
TPOX
8,9
vWA
14,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Frequent and variable abnormalities in p14 tumor suppressor gene in glioma cell lines.
Washiyama K., Kumanishi T., Uematsu Y., Itakura T.
Brain Tumor Pathol. 25:9-17(2008).
Rare-type mutations of MMAC1 tumor suppressor gene in human glioma cell lines and their tumors of origin.
Washiyama K., Kumanishi T.
Jpn. J. Cancer Res. 90:934-941(1999).
A comparative study of glioma cell lines for p16, p15, p53 and p21 gene alterations.
Washiyama K., Kumanishi T.
Jpn. J. Cancer Res. 87:900-907(1996).