COV434Homo sapiens (Human)Cancer cell line

Also known as: COV 434, COV-434

🤖 AI SummaryBased on 8 publications

Quick Overview

COV434 is a granulosa cell line derived from ovarian cancer, used in cancer research.

Detailed Summary

COV434 is a granulosa cell line established from ovarian cancer tissue, commonly used in cancer research. It is characterized by its specific genetic and molecular features, making it a valuable model for studying ovarian cancer biology. The cell line has been utilized in studies focusing on genomic profiling, drug sensitivity, and molecular mechanisms of cancer progression. Research involving COV434 has contributed to understanding the complexities of ovarian cancer, particularly in relation to genetic alterations and therapeutic responses. Its use in various studies highlights its importance in advancing cancer research and developing targeted therapies.

Research Applications

Genomic ProfilingDrug Sensitivity StudiesMolecular Mechanisms of Cancer Progression

Key Characteristics

Genetic Alterations in Ovarian CancerResponse to Therapeutic AgentsModel for Ovarian Cancer Research

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2010
Species	Homo sapiens (Human)
Tissue Source	Ovary, ovarian follicle, granulosa cell layer[UBERON:UBERON_0005170]

Donor Information

Age	26
Age Category	Adult
Sex	Female

Disease Information

Disease	Small cell carcinoma of the ovary
Lineage	Ovary/Fallopian Tube
Subtype	Small Cell Carcinoma of the Ovary
OncoTree Code	SCCO

DepMap Information

Source Type	ECACC
Source ID	ACH-000123_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	SMARCA4	c.3952-1G>C	Homozygous	Splice acceptor mutation	Unknown, PubMed=33328126

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,11

D13S317

8,12

D16S539

9,12

D18S51

10,15

D21S11

D3S1358

15,19

D5S818

10,11

D7S820

D8S1179

13,14

FGA

24,25

Penta D

10,12

Penta E

TH01

9.3

TPOX

9,11

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Re-assigning the histologic identities of COV434 and TOV-112D ovarian cancer cell lines.

Trent J.M., Weissman B.E., Huntsman D.G., Wang Y.-M.

Gynecol. Oncol. 160:568-578(2021).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Evaluating cell lines as tumour models by comparison of genomic profiles.

Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.

Nat. Commun. 4:2126.1-2126.10(2013).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Ovarian granulosa cell lines.";

Havelock J.C., Rainey W.E., Carr B.R.

Mol. Cell. Endocrinol. 228:67-78(2004).

DOI PubMed

Transcription of the gene encoding melanoma-associated antigen gp100 in tissues and cell lines other than those of the melanocytic lineage.

van der Spek C.W., Adema G.J., Schrier P.I., Figdor C.G.

Br. J. Cancer 76:1562-1566(1997).

DOI PubMed PMC

Establishment and characterization of 7 ovarian carcinoma cell lines and one granulosa tumor cell line: growth features and cytogenetics.

Cornelisse C.J., Schrier P.I.

Int. J. Cancer 53:613-620(1993).

DOI PubMed

Web Resources

culturecollections.org.uk