DERL-2Homo sapiens (Human)Cancer cell line

DERL-2 is a human T cell line derived from hepatosplenic T cell lymphoma (HSTL), a rare and aggressive form of lymphoma. This cell line is notable for its genetic profile, including mutations in genes such as SETD2, STAT5B, and PIK3CD, which are implicated in the pathogenesis of HSTL. These mutations suggest potential therapeutic targets for this aggressive malignancy. DERL-2 has been used in studies to understand the molecular mechanisms underlying HSTL, including the role of SETD2 as a tumor suppressor gene and the activation of signaling pathways such as JAK-STAT and PI3K/AKT. The cell line also exhibits specific chromosomal abnormalities, including isochromosome 7q and trisomy 8, which are common in HSTL. These characteristics make DERL-2 a valuable model for studying the genetic and molecular basis of HSTL and for developing targeted therapies.