DM-3Homo sapiens (Human)Cancer cell line
Also known as: DM3
🤖 AI SummaryBased on 4 publications
Quick Overview
DM-3 is a malignant mesothelioma cell line with sarcomatoid characteristics, used in cancer research.
Detailed Summary
DM-3 is a malignant mesothelioma cell line characterized by a sarcomatoid morphology, which is associated with aggressive tumor behavior and poor prognosis. This cell line is utilized in research to study the cytoskeletal dynamics, motility, and invasive properties of mesothelioma cells. Studies have shown that DM-3 exhibits distinct cytoskeletal organization, including prominent stress fibers and altered vimentin distribution, which contribute to its high migratory and invasive potential. Additionally, DM-3 has been used to investigate the role of the Hippo pathway and YAP nuclear localization in tumor progression. The cell line's response to various drugs, including selenite and bortezomib, has also been evaluated, highlighting its potential in developing targeted therapies for mesothelioma.
Research Applications
Cytoskeletal dynamics and cell motilityInvasive properties of mesothelioma cellsHippo pathway and YAP localizationDrug sensitivity and resistance
Key Characteristics
Sarcomatoid morphologyProminent stress fibersAltered vimentin distributionHigh migratory and invasive potentialResponse to selenite and bortezomib
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2019 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung, pleura[UBERON:UBERON_0000977] |
Donor Information
| Age | 62 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Pleural mesothelioma |
|---|---|
| Lineage | Fibroblast |
| Subtype | Fibroblast, Soft Tissue |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000742_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | SMAD4 | p.Arg496Leu (c.1487G>T) | Heterozygous | - | Unknown, Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,11
D13S317
11
D16S539
9,13
D18S51
12,15
D19S433
13,14
D21S11
29,30
D2S1338
17,18
D3S1358
15,16
D5S818
12,13
D7S820
8,10
D8S1179
11,15
FGA
19,20
Penta D
11,12
Penta E
7,12
TH01
6
TPOX
8
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Cytoskeletal organization correlates to motility and invasiveness of malignant mesothelioma cells.
Keller M., Reis K., Hjerpe A., Dobra K., Aspenstrom P.
Cancers (Basel) 13:685.1-685.20(2021).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
Variation in drug sensitivity of malignant mesothelioma cell lines with substantial effects of selenite and bortezomib, highlights need for individualized therapy.
Dobra K.
PLoS ONE 8:E65903-E65903(2013).
Establishment of permanent cell lines purified from human mesothelioma: morphological aspects, new marker expression and karyotypic analysis.
Mauel J., Spiliopoulos A.
Histochem. Cell Biol. 122:249-260(2004).
Fibroblasts cell lines misclassified as cancer cell lines.";
de Weck A., Bitter H., Kauffmann A.
bioRxiv 2017:166199-166199(2017).