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DND-41Homo sapiens (Human)Cancer cell line

Also known as: Dnd41, DND41, DND 41

🤖 AI SummaryBased on 13 publications

Quick Overview

Human T-cell acute lymphoblastic leukemia cell line with known genetic alterations.

Detailed Summary

DND-41 is a human T-cell acute lymphoblastic leukemia (T-ALL) cell line derived from a pediatric patient. It is characterized by specific genetic alterations, including mutations in the p16INK4A and p15INK4B genes, which are frequently inactivated in T-ALL. The cell line exhibits a distinct immunophenotype, expressing markers such as CD7, CD5, and CD3, and is used in studies related to T-cell differentiation and leukemogenesis. DND-41 is also notable for its role in research on the molecular mechanisms of T-ALL, including studies on the activation of TLX3 and NKX2-5 genes through remote enhancer elements. Additionally, it has been utilized in investigations of microsatellite instability and its implications in cancer progression.

Research Applications

Molecular mechanisms of T-cell leukemiaGenetic alterations in T-ALLMicrosatellite instability studiesT-cell differentiation and leukemogenesis

Key Characteristics

Mutations in p16INK4A and p15INK4B genesExpression of CD7, CD5, and CD3 markersRole in studies of TLX3 and NKX2-5 activationUtilized in microsatellite instability research

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2022
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	13
Age Category	Pediatric
Sex	Male
Subtype Features	TLX3

Disease Information

Disease	Precursor T-cell acute lymphoblastic leukemia
Lineage	Lymphoid
Subtype	T-Lymphoblastic Leukemia/Lymphoma
OncoTree Code	TLL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000981_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg248Gln (c.743G>A)	Unspecified	Somatic mutation acquired during proliferation	PubMed=20575032
MutationSimple	SMARCB1	p.Arg373Gly (c.1117A>G)	Heterozygous	-	Unknown, PubMed=22675565
MutationSimple	RET	p.Ser1002Asn (c.3005G>A)	Heterozygous	-	Unknown, PubMed=22675565
MutationSimple	RB1	p.Asp421Asn (c.1261G>A)	Heterozygous	-	Unknown, PubMed=22675565
MutationSimple	PIM1	p.Gln127Ter (c.379C>T)	Heterozygous	-	Unknown, PubMed=22675565
MutationSimple	NRAS	p.Gln61His (c.183A>C)	Unspecified	-	PubMed=21173094
MutationSimple	NOTCH1	p.Val2443fs*35 (c.7327_7327G>TGT)	Heterozygous	-	PubMed=22675565, PubMed=15472075
MutationSimple	NOTCH1	p.Asp1609Val (c.4826A>T)	Heterozygous	-	PubMed=22675565, PubMed=15472075
MutationSimple	NOTCH1	p.Leu1593Pro (c.4778T>C)	Heterozygous	-	PubMed=22675565, PubMed=15472075
MutationSimple	MAP2K4	p.Ala279Thr (c.835G>A)	Heterozygous	-	Unknown, PubMed=22675565
MutationSimple	EGFR	p.Gln71Ter (c.211C>T)	Heterozygous	-	Unknown, PubMed=22675565
Gene fusion	BCL11B	TLX3-BCL11B, HOX11L2-BCL11B	-	-	PubMed=31160637, PubMed=17308084

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,12

D13S317

10,11

D16S539

10,14

D18S51

12,17

D19S433

12,13

D21S11

29,32.2

D2S1338

18,22

D3S1358

14,18

D5S818

12,13

D7S820

8,12

D8S1179

13,14

FGA

22,26

Penta D

11,13

Penta E

7,12

TH01

8,10

TPOX

8,11

vWA

15,16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Lehtio J., Vesterlund M., Jafari R.

Nat. Commun. 13:1691.1-1691.19(2022).

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

High accuracy mutation detection in leukemia on a selected panel of cancer genes.

Cools J., Aerts S.

PLoS ONE 7:E38463-E38463(2012).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1.

Kaufmann M., Meyer C., Drexler H.G., MacLeod R.A.F.

Cancer Res. 67:1461-1471(2007).

Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.

Langerak A.W.

Leukemia 21:230-237(2007).

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.

Science 306:269-271(2004).

Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 25:275-278(2001).

Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 24:255-262(2000).

Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia.

Sekiya T., Hayashi Y.

Leuk. Res. 23:115-126(1999).

Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.

Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.

Leuk. Res. 23:19-27(1999).

p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines.

Einhorn S.

Eur. J. Haematol. 56:313-318(1996).

Interferon system defects in malignant T-cells.";

Xu B., Einhorn S.

Leukemia 8:425-434(1994).

Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:537-548(1985).

Isoenzyme studies in human leukemia-lymphoma cell lines -- III. Beta-hexosaminidase (E.C. 3.2.1.30).

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:549-559(1985).

Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. carboxylic esterase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:209-229(1985).

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

Web Resources

humantallcelllines.wordpress.com genome.ucsc.edu