DoGKiTHomo sapiens (Human)Cancer cell line
Also known as: DOGKIT
🤖 AI SummaryBased on 3 publications
Quick Overview
Human B-cell lymphoma cell line with chemotherapy resistance and specific genetic translocations.
Detailed Summary
The DoGKiT cell line is a human B-cell lymphoma cell line derived from chemotherapy-resistant patients. It exhibits specific genetic translocations, including t(8;22) and t(14;18), which are associated with aggressive lymphoma behavior. These translocations involve the c-myc and bcl-2 genes, contributing to the cell line's resistance to antitumor agents. The cell line is sensitive to various chemotherapeutics in vitro but can rapidly develop resistance under certain conditions, such as exposure to oxidative stress or repeated drug treatment. DoGKiT is used in research to study mechanisms of drug resistance and the molecular characteristics of B-cell lymphomas.
Research Applications
Study of chemotherapy resistance mechanismsInvestigation of genetic translocations in lymphomasEvaluation of antitumor drug sensitivity
Key Characteristics
Presence of t(8;22) and t(14;18) translocationsResistance to antitumor agents in vitroRapid development of drug resistance under stress conditions
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2023 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age | 57 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Burkitt lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Burkitt Lymphoma |
| OncoTree Code | BL |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001492_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,12
D13S317
9,12
D16S539
11,13
D18S51
13,16
D19S433
14
D21S11
31.2,33.2
D2S1338
19,23
D3S1358
17,18
D5S818
11
D7S820
9,11
D8S1179
13
FGA
20,23
Penta D
15,16
Penta E
7,11
TH01
6,9
TPOX
8
vWA
14,16
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines
Loading gene expression data...
Publications
Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.
Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.
Leuk. Lymphoma 57:1015-1020(2016).
A human Burkitt's lymphoma cell line carrying t(8;22) and t(14;18) translocations.
Dolken G.
Ann. Hematol. 86:821-830(2007).
Characterization of three B-cell lymphoma cell lines from chemotherapy resistant patients with respect to in vitro sensitivity to 21 antitumor agents, ABC-transporter expression and cellular redox status.
Bracht K., Kiefer T., Dolken G., Bednarski P.J.
J. Cancer Res. Clin. Oncol. 133:957-967(2007).