DOGUMHomo sapiens (Human)Cancer cell line

DOGUM is a B-cell lymphoma cell line established from chemotherapy-resistant patients. It exhibits sensitivity to various antitumor agents in vitro, with notable variations in drug response compared to other cell lines. The cell line was characterized for its in vitro sensitivity to 21 antitumor drugs, ABC transporter expression, and cellular redox status. Research indicates that DOGUM and DOGKIT were most sensitive to antitumor drugs, while DOGUM was the least sensitive. The cell line did not express measurable levels of P-glycoprotein (Pgp), MRP1, or MRP2, suggesting a lack of multidrug resistance mechanisms. Additionally, DOGUM showed moderate variations in its antioxidative defense system, with GPx activity increasing after pre-treatment with hydrogen peroxide. The cell line's ability to rapidly adapt to toxic insults may contribute to clinical resistance observed in patients.