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EB1Homo sapiens (Human)Cancer cell line

Also known as: Epstein-Barr-1, EB-1

🤖 AI SummaryBased on 12 publications

Quick Overview

Human B cell line from Burkitt's lymphoma, used in cancer research.

Detailed Summary

The EB1 cell line is a human B cell line derived from Burkitt's lymphoma, established in continuous culture. It is characterized by its ability to grow as free-floating cells without attachment to glass, with a typical round morphology and occasional pear-shaped or elongated forms. The cells exhibit a high proliferation rate, with a mean doubling time of 48 hours under optimal conditions. EB1 has been utilized in studies related to viral infections, particularly Epstein-Barr virus (EBV), and in understanding the molecular mechanisms of lymphoma. The cell line is also used for investigating cell growth patterns, genetic alterations, and responses to various experimental conditions in cancer research.

Research Applications

Cancer researchViral infection studies (EBV)Cell growth and proliferation analysisGenetic and molecular studies

Key Characteristics

Continuous cultureFree-floating growthB cell originHigh proliferation rate
Generated on 6/18/2025

Basic Information

Database IDCVCL_2027
SpeciesHomo sapiens (Human)
Tissue SourceBone, jaw, maxilla[UBERON:UBERON_0002397]

Donor Information

Age9
Age CategoryPediatric
SexFemale
Raceblack_or_african_american

Disease Information

DiseaseBurkitt lymphoma
LineageLymphoid
SubtypeBurkitt Lymphoma
OncoTree CodeBL

DepMap Information

Source TypeATCC
Source IDACH-000877_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Gly244Asp (c.731G>A)Unspecified-PubMed=28273451

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
10,12
D13S317
11,13
D16S539
8,10
D18S51
15,16
D19S433
14,14.2
D21S11
30,32.2
D2S1338
21,24
D3S1358
16,17
D5S818
8,12
D7S820
10,12
D8S1179
14,15
FGA
24,30
Penta D
6.3,13
Penta E
13,17
TH01
9,9.3
TPOX
8,9
vWA
14,16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOIPubMedPMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOIPubMedPMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOIPubMedPMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOIPubMedPMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOIPubMedPMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOIPubMedPMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOIPubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOIPubMed

Comprehensive cytogenetic and molecular cytogenetic analysis of 44 Burkitt lymphoma cell lines: secondary chromosomal changes characterization, karyotypic evolution, and comparison with primary samples.

Vettorazzi E., Bokemeyer C., Dierlamm J.

Genes Chromosomes Cancer 53:497-515(2014).

DOIPubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOIPubMedPMC

Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.

Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.

J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010).

DOIPubMedPMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOIPubMedPMC

Fine structural organization of human lymphoblasts of a tissue culture strain (EB1) from Burkitt's lymphoma.

Epstein M.A., Achong B.G.

J. Natl. Cancer Inst. 34:241-253(1965).

DOIPubMed

Characteristics and mode of growth of tissue culture strain (EB1) of human lymphoblasts from Burkitt's lymphoma.

Epstein M.A., Barr Y.M.

J. Natl. Cancer Inst. 34:231-240(1965).

DOIPubMed

Cultivation in vitro of human lymphoblasts from Burkitt's malignant lymphoma.

Epstein M.A., Barr Y.M.

Lancet 283:252-253(1964).

DOIPubMed

Detection of clonal EBV episomes in lymphoproliferations as a diagnostic tool.

van Dongen J.J.M.

Leukemia 16:1572-1573(2002).

DOIPubMed

The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.

Quentmeier H., Drexler H.G.

Leukemia 10:142-149(1996).

PubMed

Variable IgH chain enhancer activity in Burkitt's lymphomas suggests an additional, direct mechanism of c-myc deregulation.

Jain V.K., Judde J.-G., Max E.E., Magrath I.T.

J. Immunol. 150:5418-5428(1993).

DOIPubMed

Differences in genetic stability between human cell lines from patients with and without lymphoreticular malignancy.

Povey S., Jeremiah S., Arthur E., Steel M., Klein G.

Ann. Hum. Genet. 44:119-133(1980).

DOIPubMed

Chromosome studies of 8 in vitro lines of Burkitt's lymphoma.";

Miles C.P., O'Neill F.

Cancer Res. 27:392-402(1967).

PubMed

Studies with Burkitt's lymphoma.";

Epstein M.A., Barr Y.M., Achong B.G.

Wistar Inst. Symp. Monogr. 4:69-82(1965).

PubMed

Heterotransplantability of human cell lines derived from leukemia and lymphomas into immunologically tolerant rats.

McComb V.

Cancer 24:211-222(1969).

DOIPubMed

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

DOIPubMed

The cytogenetics of human B lymphoid malignancy: studies in Burkitt's lymphoma and Epstein-Barr virus-transformed lymphoblastoid cell lines.

Steel C.M., Morten J.E.N., Foster E.

IARC Sci. Publ. 60:265-292(1985).

PubMed

Web Resources

tcpaportal.org