ESO-26Homo sapiens (Human)Cancer cell line
Also known as: ESO26
🤖 AI SummaryBased on 4 publications
Quick Overview
Human esophageal adenocarcinoma cell line for cancer research.
Detailed Summary
ESO-26 is a human esophageal adenocarcinoma (EAC) cell line derived from a primary tumor. It is one of the 10 verified EAC cell lines that have been authenticated through genotyping and TP53 mutation analysis. These cell lines are used in research to study the molecular mechanisms of EAC and to develop targeted therapies. ESO-26 is part of a panel of cell lines that have been validated for their genetic consistency with the original tumors, ensuring their reliability for in vitro and in vivo studies. The cell line is available in public repositories to support cancer research and drug development.
Research Applications
Cancer researchMolecular mechanisms of EACDrug development
Key Characteristics
Authenticity verified through genotypingTP53 mutation analysisAvailable in public repositories
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2035 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Esophagus, distal[UBERON:UBERON_0013473] |
Donor Information
| Age | 56 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Carcinoma of esophagus |
|---|---|
| Lineage | Esophagus/Stomach |
| Subtype | Adenocarcinoma of the Gastroesophageal Junction |
| OncoTree Code | GEJ |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001496_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg248Trp (c.742C>T) | Homozygous | Somatic mutation acquired during proliferation | from parent cell line VCaP |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
9,10
D13S317
9,11
D16S539
9
D18S51
17
D19S433
14
D21S11
30
D2S1338
19,23
D3S1358
15
D5S818
12
D7S820
11
D8S1179
13,14
FGA
21
Penta D
10
Penta E
12,14
TH01
9
TPOX
7,9
vWA
14,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.";
Lynch A.G., Edwards P.A.W., Fitzgerald R.C.
F1000Research 5:1336.1-1336.12(2016).
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Boonstra J.J., Tilanus H.W., Dinjens W.N.M.
Dis. Esophagus 28:90-96(2015).