ESO-51Homo sapiens (Human)Cancer cell line
Also known as: ESO51
🤖 AI SummaryBased on 4 publications
Quick Overview
Human esophageal adenocarcinoma cell line for cancer research.
Detailed Summary
ESO-51 is a human esophageal adenocarcinoma (EAC) cell line derived from a primary tumor. It is one of the 10 verified EAC cell lines that have been authenticated through genotyping and short tandem repeat (STR) profiling. These cell lines are used to study the molecular mechanisms of EAC and to develop targeted therapies. ESO-51 has been shown to retain the TP53 mutations present in the original tumor, making it a valuable model for studying genetic alterations in EAC. The cell line is also used in research on drug discovery and therapeutic strategies for EAC, contributing to the understanding of tumor biology and treatment responses.
Research Applications
Cancer researchDrug discoveryMolecular mechanisms of EACGenetic alterations in EAC
Key Characteristics
Retains TP53 mutations from original tumorUsed for in vitro studiesPart of a verified panel of EAC cell lines
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2036 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Esophagus, distal[UBERON:UBERON_0013473] |
Donor Information
| Age | 74 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Adenocarcinoma of the esophagus |
|---|---|
| Lineage | Esophagus/Stomach |
| Subtype | Esophageal Adenocarcinoma |
| OncoTree Code | ESCA |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001497_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg175His (c.524G>A) | Unspecified | Somatic mutation acquired during proliferation | from parent cell line YCC-3 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
11
D16S539
13
D18S51
17,20
D19S433
12
D21S11
30,33.2
D2S1338
25
D3S1358
15,16
D5S818
11
D7S820
8
D8S1179
10
FGA
21,22
Penta D
9,13
Penta E
17
TH01
9
TPOX
8
vWA
14,15
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.";
Lynch A.G., Edwards P.A.W., Fitzgerald R.C.
F1000Research 5:1336.1-1336.12(2016).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Boonstra J.J., Tilanus H.W., Dinjens W.N.M.
Dis. Esophagus 28:90-96(2015).