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F-36PHomo sapiens (Human)Cancer cell line

Also known as: F36P

🤖 AI SummaryBased on 7 publications

Quick Overview

F-36P is a human cell line derived from myeloid leukemia, characterized by the JAK2 V617F mutation and associated with myelopro...

Detailed Summary

F-36P is a human cell line established from a patient with myeloid leukemia, known for harboring the JAK2 V617F mutation, which is commonly associated with myeloproliferative disorders such as polycythemia vera and essential thrombocythemia. This cell line is utilized in research to study the molecular mechanisms of JAK2 mutations and their role in leukemogenesis. The presence of the JAK2 V617F mutation makes F-36P a valuable tool for investigating targeted therapies against JAK2 signaling pathways. Additionally, F-36P has been used to explore the genetic and epigenetic alterations linked to myeloproliferative neoplasms, contributing to the understanding of disease progression and therapeutic resistance.

Research Applications

Study of JAK2 V617F mutation in myeloproliferative disordersInvestigation of JAK2 signaling pathways in leukemogenesisDevelopment of targeted therapies against JAK2 mutationsAnalysis of genetic and epigenetic alterations in myeloproliferative neoplasms

Key Characteristics

JAK2 V617F mutationMyeloid leukemia originRelevance to myeloproliferative disorders

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2037
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age	68
Age Category	Adult
Sex	Male

Disease Information

Disease	Myelodysplastic syndrome
Lineage	Myeloid
Subtype	Myelodysplastic Syndromes
OncoTree Code	MDS

DepMap Information

Source Type	DSMZ
Source ID	ACH-000487_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21)	Unspecified	Splice acceptor mutation	from parent cell line U-1285
MutationSimple	KMT2A	p.Glu766Gln (c.2296G>C)	Heterozygous	-	Unknown, PubMed=27750403

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

9

D13S317

10

D16S539

10,12

D18S51

15

D19S433

12,13

D21S11

31

D2S1338

17

D3S1358

15

D5S818

13

D7S820

9,11

D8S1179

12,15

FGA

21,24

Penta D

10,11

Penta E

16,17

TH01

8

TPOX

9,11

vWA

14,16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

Immunophenotypic, cytogenetic, and mutational characterization of cell lines derived from myelodysplastic syndrome patients after progression to acute myeloid leukemia.

Campos D., Granada I., Junca J., Drexler H.G., Sole F., Buschbeck M.

Genes Chromosomes Cancer 56:243-252(2017).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.

Haferlach T., Shirahige K., Miyano S., Ogawa S.

Nat. Genet. 45:1232-1237(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

Establishment and erythroid differentiation of a cytokine-dependent human leukemic cell line F-36: a parental line requiring granulocyte-macrophage colony-stimulating factor or interleukin-3, and a subline requiring erythropoietin.

Miyagawa K., Yazaki Y., Hirai H.

Blood 78:2261-2268(1991).

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

Web Resources