FLO-1Homo sapiens (Human)Cancer cell line

Also known as: FLO, FLO1, Flo 1, Flo-1

🤖 AI SummaryBased on 4 publications

Quick Overview

Human esophageal adenocarcinoma cell line for cancer research.

Detailed Summary

FLO-1 is a human esophageal adenocarcinoma (EAC) cell line derived from a primary tumor. It is one of the 10 verified EAC cell lines that have been authenticated and are used in cancer research. These cell lines are crucial for studying the molecular mechanisms of EAC and for developing targeted therapies. FLO-1 is part of a panel of cell lines that have been validated for their genetic and phenotypic consistency with their original tumors, making them reliable models for in vitro and in vivo studies. The cell line is used in research to understand tumor biology, drug discovery, and the evaluation of therapeutic strategies. It is also part of repositories that provide access to high-quality cell lines for the scientific community.

Research Applications

Cancer researchDrug discoveryMolecular mechanism studiesIn vitro and in vivo modeling

Key Characteristics

Authenticity verifiedGenetically consistent with original tumorUsed in translational research

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2045
Species	Homo sapiens (Human)
Tissue Source	Esophagus[UBERON:UBERON_0001043]

Donor Information

Age	68
Age Category	Adult
Sex	Male

Disease Information

Disease	Adenocarcinoma of the esophagus
Lineage	Esophagus/Stomach
Subtype	Esophageal Adenocarcinoma
OncoTree Code	ESCA

DepMap Information

Source Type	Sigma-Aldrich
Source ID	ACH-001500_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Cys277Phe (c.830G>T)	Unspecified	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

12,13

D18S51

14,16

D19S433

D21S11

30,32.2

D2S1338

17,24

D3S1358

D5S818

12,14

D7S820

D8S1179

FGA

Penta D

11,12

Penta E

5,17

TH01

TPOX

9,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.";

Lynch A.G., Edwards P.A.W., Fitzgerald R.C.

F1000Research 5:1336.1-1336.12(2016).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Translational research on esophageal adenocarcinoma: from cell line to clinic.

Boonstra J.J., Tilanus H.W., Dinjens W.N.M.

Dis. Esophagus 28:90-96(2015).

DOI PubMed

Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.

Shimada Y., van Dekken H., Tilanus H.W., Dinjens W.N.M.

J. Natl. Cancer Inst. 102:271-274(2010).

DOI PubMed PMC

Induction of glutathione s-transferase-pi in Barrett's metaplasia and Barrett's adenocarcinoma cell lines.

Compton K.R., Orringer M.B., Beer D.G.

Mol. Carcinog. 24:128-136(1999).

DOI PubMed

Fas/APO-1 (CD95) is not translocated to the cell membrane in esophageal adenocarcinoma.

Iannettoni M.D., Orringer M.B., Beer D.G.

Cancer Res. 57:5571-5578(1997).

PubMed