FU-OV-1Homo sapiens (Human)Cancer cell line

Also known as: Fukuoka University-OVarian-1, FUOV1, FUOV-1

🤖 AI SummaryBased on 10 publications

Quick Overview

Ovarian cancer cell line with c-myc amplification, established from serous papillary adenocarcinoma.

Detailed Summary

FU-OV-1 is a human ovarian cancer cell line derived from a serous papillary adenocarcinoma. It exhibits c-myc gene amplification, which is associated with tumor progression. The cell line maintains characteristics of the original tumor and has been used to study biological behaviors of serous papillary adenocarcinoma. It has been propagated in serum-free culture conditions and shows continuous growth over multiple passages. The cell line is valuable for investigating molecular mechanisms and therapeutic strategies in ovarian cancer research.

Research Applications

Molecular mechanisms of ovarian cancerTherapeutic strategies developmentc-myc amplification studies

Key Characteristics

c-myc gene amplificationSerous papillary adenocarcinoma originContinuous growth in serum-free culture
Generated on 6/18/2025

Basic Information

Database IDCVCL_2047
SpeciesHomo sapiens (Human)
Tissue SourceOvary[UBERON:UBERON_0000992]

Donor Information

Age65
Age CategoryAdult
SexFemale
Raceasian

Disease Information

DiseaseHigh grade ovarian serous adenocarcinoma
LineageOvary/Fallopian Tube
SubtypeHigh-Grade Serous Ovarian Cancer
OncoTree CodeHGSOC

DepMap Information

Source TypeDSMZ
Source IDACH-000574_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.His179Asp (c.535C>G)Unspecified-PubMed=15035290

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
10,12
D13S317
8,10
D16S539
12
D18S51
14
D19S433
13
D21S11
29,30
D2S1338
17,19
D3S1358
15
D5S818
11,13
D7S820
11
D8S1179
11,12
FGA
20
Penta D
10,13
Penta E
11
TH01
6
TPOX
8,9
vWA
14,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.

Velculescu V.E., Scharpf R.B.

Cell Rep. 25:2617-2633(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

Evaluating cell lines as tumour models by comparison of genomic profiles.

Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.

Nat. Commun. 4:2126.1-2126.10(2013).

BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.

Mills G.B., Hennessy B.T.

Mol. Oncol. 7:567-579(2013).

DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.

Lessey B.A., Jordan V.C., Bradford A.P.

Gynecol. Oncol. 127:241-248(2012).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Establishment and characterization of a serous papillary adenocarcinoma cell line of the human ovary in a serum-free culture.

Kikuchi M.

Pathol. Res. Pract. 195:237-242(1999).

Web Resources