GOS-3Homo sapiens (Human)Cancer cell line

Also known as: GOS3, GOS 3

🤖 AI SummaryBased on 5 publications

Quick Overview

GOS-3 is a human glioma cell line used in cancer research.

Detailed Summary

GOS-3 is a human glioma cell line established from a mixed astrocytoma grade III/III. It is used in research for studying glioma biology, drug sensitivity, and genetic characteristics. The cell line exhibits specific genetic markers and has been utilized in studies related to cancer cell line diversity and ancestry. GOS-3 is part of a panel of cell lines used to investigate the molecular mechanisms of gliomas and their response to various treatments.

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2050
Species	Homo sapiens (Human)
Tissue Source	Brain, temporal lobe[UBERON:UBERON_0001871]

Donor Information

Age	64
Age Category	Adult
Sex	Male

Disease Information

Disease	Glioblastoma
Lineage	CNS/Brain
Subtype	Glioblastoma
OncoTree Code	GB

DepMap Information

Source Type	DSMZ
Source ID	ACH-000027_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,12

D13S317

9,13

D16S539

9,12

D18S51

D19S433

13,14

D21S11

D2S1338

22,24

D3S1358

15,17

D5S818

12,13

D7S820

9,11

D8S1179

13,14

FGA

19,20

Penta D

9,10

Penta E

10,12

TH01

6,9.3

TPOX

8,9

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

DNA fingerprinting of glioma cell lines and considerations on similarity measurements.

Hamou M.-F., Delorenzi M., Hegi M.E.

Neuro-oncol. 14:701-711(2012).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Growth inhibition of newly established human glioma cell lines by leukemia inhibitory factor.

Ringelstein E.B., Stogbauer F.

J. Neurooncol. 39:1-18(1998).

DOI PubMed

Brain tumors.";

Ali-Osman F.

(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999).

DOI

Web Resources

iclac.org