GUMBUSHomo sapiens (Human)Cancer cell line
Also known as: Gumbus
🤖 AI SummaryBased on 3 publications
Quick Overview
GUMBUS is a B-cell lymphoma cell line derived from chemotherapy-resistant patients, showing sensitivity to antitumor agents aft...
Detailed Summary
GUMBUS is a B-cell lymphoma cell line that was established from chemotherapy-resistant patients. It exhibits sensitivity to various antitumor agents after being cultured in vitro for 15-18 weeks. The cell line shows moderate variation in its antioxidative defense system and does not express measurable levels of P-glycoprotein (Pgp), multidrug resistance related proteins (MRP1, MRP2), or other ABC transporters. GUMBUS demonstrates sensitivity to multiple chemotherapeutic agents, although this sensitivity can be rapidly decreased in vitro under conditions of oxidative stress or repeated exposure to antitumor drugs. The cell line's ability to adapt to toxic insults in its environment may contribute to clinical resistance observed in patients. GUMBUS is used in research to study mechanisms of drug resistance and to evaluate the efficacy of cancer therapies.
Research Applications
Study of chemotherapy resistance mechanismsEvaluation of antitumor drug efficacyInvestigation of oxidative stress effects on drug sensitivity
Key Characteristics
Sensitivity to antitumor agents after in vitro cultureLack of ABC transporter expressionModerate antioxidative defense systemRapid adaptation to toxic environments
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2051 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 28 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Burkitt lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Burkitt Lymphoma |
| OncoTree Code | BL |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001503_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11,12
D13S317
12,13
D16S539
11
D18S51
14,16
D19S433
14,15
D21S11
30,31.2
D2S1338
17,19
D3S1358
14,15
D5S818
10,13
D7S820
8,10
D8S1179
13,16
FGA
19,20
Penta D
10,12
Penta E
10,14
TH01
9.3
TPOX
11
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
OncoImmunology 3:e954893.1-e954893.12(2014).
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.
Waldmann T.A., Rowe M., Mbulaiteye S.M., Rickinson A.B., Staudt L.M.
Nature 490:116-120(2012).
Characterization of three B-cell lymphoma cell lines from chemotherapy resistant patients with respect to in vitro sensitivity to 21 antitumor agents, ABC-transporter expression and cellular redox status.
Bracht K., Kiefer T., Dolken G., Bednarski P.J.
J. Cancer Res. Clin. Oncol. 133:957-967(2007).