HCC202Homo sapiens (Human)Cancer cell line

Also known as: Hamon Cancer Center 202, HCC0202, HCC-202

🤖 AI SummaryBased on 13 publications

Quick Overview

Human breast cancer cell line with known genetic and molecular characteristics.

Detailed Summary

HCC202 is a human breast cancer cell line derived from a primary tumor. It is characterized by specific genetic alterations, including mutations in key oncogenes and tumor suppressor genes, which are commonly associated with aggressive breast cancer subtypes. This cell line is widely used in research to study the molecular mechanisms of breast cancer progression and drug resistance. HCC202 has been utilized in multiple studies to identify potential therapeutic targets and to evaluate the efficacy of various anticancer drugs. Its genetic profile makes it a valuable model for understanding the complexities of breast cancer biology and for developing targeted therapies.
Generated on 6/18/2025

Basic Information

Database IDCVCL_2062
SpeciesHomo sapiens (Human)
Tissue SourceBreast[UBERON:UBERON_0000310]

Donor Information

Age82
Age CategoryAdult
SexFemale
Racecaucasian
Subtype FeaturesHER2+

Disease Information

DiseaseBreast ductal carcinoma
LineageBreast
SubtypeBreast Ductal Carcinoma In Situ
OncoTree CodeDCIS

DepMap Information

Source TypeATCC
Source IDACH-000725_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Thr284Argfs*21 (c.851_852delCA) (p.R283fs, c.849_850del2)Heterozygous-Unknown, Unknown
MutationSimplePIK3CAp.Glu545Lys (c.1633G>A)Heterozygous-from parent cell line MCF-7

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
10
D13S317
8,9
D16S539
13
D18S51
17
D19S433
14
D21S11
26
D2S1338
20,23
D3S1358
16
D5S818
11,13
D7S820
8,12
D8S1179
13,15
FGA
24
Penta D
12,15
Penta E
8
TH01
6
TPOX
8,9
vWA
16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Modeling precision treatment of breast cancer.";

Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.

Genome Biol. 14:R110.1-R110.14(2013).

Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.

McCormick F., Gray J.W.

Cancer Cell 24:450-465(2013).

miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.

Martens J.W.M.

Breast Cancer Res. 15:R33.1-R33.17(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Proteomic portrait of human breast cancer progression identifies novel prognostic markers.

Geiger T., Madden S.F., Gallagher W.M., Cox J., Mann M.

Cancer Res. 72:2428-2439(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.

Pollack J.R.

PLoS ONE 4:E6146-E6146(2009).

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.

Johnson M.D., Lippman M.E., Ethier S.P., Gazdar A.F., Gray J.W.

Cancer Cell 10:515-527(2006).

Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.

Minna J.D.

Oncogene 20:1005-1009(2001).

Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer.

Tomlinson G.E., Tonk V., Ashfaq R., Leitch A.M., Minna J.D., Shay J.W.

Int. J. Cancer 78:766-774(1998).