HDQ-P1Homo sapiens (Human)Cancer cell line

Also known as: HDQP1

🤖 AI SummaryBased on 6 publications

Quick Overview

Human breast cancer cell line with unique molecular characteristics.

Detailed Summary

The HDQ-P1 cell line was established from a primary ductal infiltrating mammary carcinoma and has been cultured for over 115 passages. It exhibits an epithelial morphology with features such as polygonal cells, large nuclei, and abnormal mitotic figures. The cell line shows a polyploid karyotype with 20 recurrent marker chromosomes. HDQ-P1 is negative for estrogen and progesterone receptors and expresses human telomerase reverse transcriptase (hTERT) similar to other breast cancer cell lines. It has a five-fold amplification of the C-MYC gene but no amplification of C-ERBB-2 or C-H-RAS. The cell line is capable of anchorage-independent growth and shows tumorigenic potential in nude mice, although tumor formation was not observed in all experiments. HDQ-P1 is used in research for studying breast cancer biology, drug sensitivity, and molecular mechanisms of tumorigenesis.

Research Applications

Breast cancer biologyDrug sensitivity testingMolecular mechanisms of tumorigenesisGenomic and proteomic profiling

Key Characteristics

Epithelial morphologyPolyploid karyotypeNegative for estrogen and progesterone receptorsAmplified C-MYCTumorigenic in nude miceAnchorage-independent growth

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2067
Species	Homo sapiens (Human)
Tissue Source	Breast[UBERON:UBERON_0000310]

Donor Information

Age	50
Age Category	Adult
Sex	Female
Race	caucasian
Subtype Features	basal_A TNBC

Disease Information

Disease	Breast ductal carcinoma
Lineage	Breast
Subtype	Breast Invasive Ductal Carcinoma
OncoTree Code	IDC

DepMap Information

Source Type	DSMZ
Source ID	ACH-000643_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg213Ter (c.637C>T)	Unspecified	-	Unknown
MutationSimple	TMPRSS2	p.Gly8Val (c.23G>T) (c.-57+99G>T)	Heterozygous	-	PubMed=34339474
MutationSimple	KDM6A	p.Arg165Ter (c.493C>T)	Homozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D10S1248

13,14

D12S391

19,21

D13S317

D16S539

D18S51

D19S433

D1S1656

13,16.3

D21S11

D22S1045

D2S1338

D2S441

D3S1358

D5S818

D7S820

11,12

D8S1179

12,15

FGA

Penta D

Penta E

11,13

TH01

9.3

TPOX

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies.

Safranko Z.M., Kurolt I.-C., Markotic A., Cicin-Sain L., Steenpass L.

PLoS ONE 16:E0255622-E0255622(2021).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

Modeling precision treatment of breast cancer.";

Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.

Genome Biol. 14:R110.1-R110.14(2013).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Establishment and characterization of a new cell line derived from a human primary breast carcinoma.

Germain L., Tetu B.

Cancer Genet. Cytogenet. 120:58-72(2000).

DOI PubMed

Web Resources

tcpaportal.org