IGR-37Homo sapiens (Human)Cancer cell line
Also known as: Institut Gustave Roussy-37, MM1, IGR37, IGR 37, IgR-37
Quick Overview
IGR-37 is a human melanoma cell line derived from a metastatic lymph node, used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_2075 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Inguinal lymph node[UBERON:UBERON_0001542] |
Donor Information
| Age | 26 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000650_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Cys229Tyrfs*10 (c.686_687delGT) | Unspecified | - | from parent cell line IGR-39 |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Identification of genetic disparity between primary and metastatic melanoma in human patients.
Petzelbauer P., Mikula M.
Genes Chromosomes Cancer 50:680-688(2011).
Immunocytochemical analysis of cell lines derived from solid tumors.
Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.
J. Histochem. Cytochem. 49:1369-1378(2001).
The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines.
Brinker M.G.L., Ruiters M.H.J., de Leij L.F.M.H., Buys C.H.C.M.
Int. J. Cancer 85:871-876(2000).
Tumorigenicity of human malignant melanocytes in nude mice in relation to their differentiation in vitro.
Aubert C., Rouge F., Galindo J.-R.
J. Natl. Cancer Inst. 64:1029-1040(1980).
Discrimination between human melanoma cell lines by fluorescence anisotropy.
Weinreb A., Travo P.
Eur. J. Cancer Clin. Oncol. 20:673-677(1984).
WGA binding to the surface of two autologous human melanoma cell lines: different expression of sialyl and N-acetylglucosaminyl residues.
Aubery M., Reynier M., Lopez M., Ogier-Denis E., Font J., Bardin F.
Cell Biol. Int. Rep. 14:275-286(1990).
Calmodulin content and distribution in six human melanoma cell lines.
Aquaron R., Dutoit C., Reynier M., Aubert C.
Cell. Mol. Biol. 36:85-92(1990).