IGR-39Homo sapiens (Human)Cancer cell line

Also known as: Institut Gustave Roussy-39, PM1, IGR39, IGR 39

🤖 AI SummaryBased on 10 publications

Quick Overview

Human melanoma cell line with distinct genetic and phenotypic characteristics.

Detailed Summary

IGR-39 is a human melanoma cell line derived from a primary tumor, characterized by specific genetic and phenotypic features. It exhibits unique patterns of tyrosinase localization and melanin synthesis, which are critical for understanding melanoma biology. The cell line has been used in studies investigating the role of genetic alterations in tumor progression and drug sensitivity. Research on IGR-39 has contributed to the understanding of melanoma heterogeneity and the identification of potential therapeutic targets. Its properties make it a valuable model for studying melanoma development and response to treatments.

Research Applications

Melanoma biologyGenetic alterations in tumor progressionDrug sensitivity profilingTyrosinase localization studies

Key Characteristics

Distinct melanin synthesis patternsGenetic heterogeneityTyrosinase activityPotential therapeutic target identification

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2076
Species	Homo sapiens (Human)
Tissue Source	Skin[UBERON:UBERON_0002097]

Donor Information

Age	26
Age Category	Adult
Sex	Male

Disease Information

Disease	Melanoma
Lineage	Skin
Subtype	Melanoma
OncoTree Code	MEL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000550_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Cys229Tyrfs*10 (c.686_687delGT)	Unspecified	-	from parent cell line IGR-39
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2
MutationSimple	BRAF	p.Val600Glu (c.1799T>A)	Unspecified	-	PubMed=26214590
Gene deletion	PTEN	-	Hemizygous	-	Wistar

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,12

D13S317

D16S539

D18S51

D19S433

D21S11

31.2,32.2

D2S1338

19,24

D3S1358

17,18

D5S818

11,12

D7S820

10,11

D8S1179

14,15

FGA

Penta D

Penta E

12,16

TH01

TPOX

8,11

vWA

17,21

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.

Borg A., Pawelec G., Guldberg P.

Mol. Cancer Res. 11:1166-1178(2013).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Identification of genetic disparity between primary and metastatic melanoma in human patients.

Petzelbauer P., Mikula M.

Genes Chromosomes Cancer 50:680-688(2011).

DOI PubMed

High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.

Garrido F.

Cancer Immunol. Immunother. 54:141-148(2005).

DOI PubMed PMC

Immunocytochemical analysis of cell lines derived from solid tumors.

Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.

J. Histochem. Cytochem. 49:1369-1378(2001).

DOI PubMed

Tumorigenicity of human malignant melanocytes in nude mice in relation to their differentiation in vitro.

Aubert C., Rouge F., Galindo J.-R.

J. Natl. Cancer Inst. 64:1029-1040(1980).

DOI PubMed

Discrimination between human melanoma cell lines by fluorescence anisotropy.

Weinreb A., Travo P.

Eur. J. Cancer Clin. Oncol. 20:673-677(1984).

DOI PubMed

WGA binding to the surface of two autologous human melanoma cell lines: different expression of sialyl and N-acetylglucosaminyl residues.

Aubery M., Reynier M., Lopez M., Ogier-Denis E., Font J., Bardin F.

Cell Biol. Int. Rep. 14:275-286(1990).

DOI PubMed

Calmodulin content and distribution in six human melanoma cell lines.

Aquaron R., Dutoit C., Reynier M., Aubert C.

Cell. Mol. Biol. 36:85-92(1990).

PubMed

Cellular localization of tyrosinase in human malignant melanoma cell lines.

Foa C., Aubert C.

J. Invest. Dermatol. 68:369-378(1977).

DOI PubMed