JK-1Homo sapiens (Human)Cancer cell line

Also known as: JK1

🤖 AI SummaryBased on 8 publications

Quick Overview

JK-1 is a human chronic myeloid leukemia cell line derived from a patient with Philadelphia chromosome-positive disease.

Detailed Summary

JK-1 is a human chronic myeloid leukemia (CML) cell line established from a patient with Philadelphia chromosome-positive CML. It is characterized by the presence of the BCR-ABL fusion gene, which results from the t(9;22)(q34;q11) translocation. This cell line is widely used in research to study the molecular mechanisms of CML and the effects of targeted therapies such as tyrosine kinase inhibitors. JK-1 has been utilized in studies investigating the genetic and molecular alterations associated with CML progression and drug resistance. It is also part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in various genomic and pharmacological studies to identify biomarkers and therapeutic targets.

Research Applications

Study of BCR-ABL fusion gene and its role in CMLInvestigation of tyrosine kinase inhibitor resistanceGenomic and pharmacological profilingIdentification of biomarkers and therapeutic targets

Key Characteristics

Presence of Philadelphia chromosome (t(9;22)(q34;q11))Expression of BCR-ABL fusion proteinUsed in studies of CML progression and drug resistance

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2079
Species	Homo sapiens (Human)

Donor Information

Age	58
Age Category	Adult
Sex	Male
Subtype Features	BCR-ABL1 positive

Disease Information

Disease	Chronic myeloid leukemia
Lineage	Myeloid
Subtype	Chronic Myeloid Leukemia, BCR-ABL1+
OncoTree Code	CMLBCRABL1

DepMap Information

Source Type	DSMZ
Source ID	ACH-000241_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
Gene fusion	ABL1	BCR-ABL1, BCR-ABL	-	BCR exon 1 fused to ABL1 exon 2	PubMed=10576511, PubMed=10071072, PubMed=8751477

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

9,13

D16S539

9,13

D18S51

14,19

D19S433

D21S11

29,31

D2S1338

17,19

D3S1358

D5S818

D7S820

D8S1179

12,13

FGA

21,25

Penta D

11,14

Penta E

16,18

TH01

6,9

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in chronic myeloid leukaemia: a FISH mapping study of CML patients and cell lines.

Virgili A., Nacheva E.

Mol. Cytogenet. 3:15.1-15.12(2010).

DOI PubMed PMC

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

DOI PubMed

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

Fioretos T.

Leukemia 19:1042-1050(2005).

DOI PubMed

ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";

Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.

Leuk. Res. 23:1055-1060(1999).

DOI PubMed

Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.

Drexler H.G., MacLeod R.A.F., Uphoff C.C.

Leuk. Res. 23:207-215(1999).

DOI PubMed

Establishment of an erythroid cell line (JK-1) that spontaneously differentiates to red cells.

Sasaki R., Tada K., Imura H.

Cancer 66:1544-1551(1990).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI