JL-1Homo sapiens (Human)Cancer cell line

Also known as: JL1

🤖 AI SummaryBased on 6 publications

Quick Overview

JL-1 is a human cancer cell line used in research for its specific characteristics.

Detailed Summary

JL-1 is a human cancer cell line derived from a tumor, though the specific tissue of origin is unknown. It is characterized by its morphological features and has been used in studies related to cancer cell line diversity and drug sensitivity. Research on JL-1 has contributed to understanding the variability in cancer cell behavior and response to treatments. The cell line is part of various studies focusing on the genetic and molecular profiles of cancer cells, aiding in the development of targeted therapies.

Research Applications

Cancer researchDrug sensitivity studiesGenetic and molecular profiling

Key Characteristics

Morphological variabilityDrug response variabilityPart of cancer cell line diversity studies

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2080
Species	Homo sapiens (Human)
Tissue Source	Lung, pleura[UBERON:UBERON_0000977]

Donor Information

Age	54
Age Category	Adult
Sex	Male

Disease Information

Disease	Pleural mesothelioma
Lineage	Pleura
Subtype	Pleural Mesothelioma, Epithelioid Type
OncoTree Code	PLEMESO

DepMap Information

Source Type	DSMZ
Source ID	ACH-000645_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

D16S539

9,12

D18S51

14,15

D19S433

D21S11

D2S1338

17,19

D3S1358

D5S818

12,13

D7S820

9,11

D8S1179

FGA

22,23

Penta D

11,12

Penta E

11,13

TH01

8,9.3

TPOX

9,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Cytoskeletal organization correlates to motility and invasiveness of malignant mesothelioma cells.

Keller M., Reis K., Hjerpe A., Dobra K., Aspenstrom P.

Cancers (Basel) 13:685.1-685.20(2021).

DOI PubMed PMC

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Variation in drug sensitivity of malignant mesothelioma cell lines with substantial effects of selenite and bortezomib, highlights need for individualized therapy.

Dobra K.

PLoS ONE 8:E65903-E65903(2013).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Establishment of permanent cell lines purified from human mesothelioma: morphological aspects, new marker expression and karyotypic analysis.

Mauel J., Spiliopoulos A.

Histochem. Cell Biol. 122:249-260(2004).

DOI PubMed