JMSU-1Homo sapiens (Human)Cancer cell line
Also known as: JMSU1
🤖 AI SummaryBased on 7 publications
Quick Overview
Human bladder cancer cell line with diverse mutations and potential for cancer research.
Detailed Summary
JMSU-1 is a human bladder cancer cell line established from malignant ascitic fluid of a 75-year-old Japanese man. It has been cultured for over 7 years and has undergone more than 240 passages. The cell line exhibits morphological heterogeneity in vitro, with distinct polygonal to spindle-shaped cells. JMSU-1 shows tumorigenicity in vivo, forming poorly differentiated transitional cell carcinomas in nude mice. It has been characterized for genetic mutations, including TERT promoter mutations, and is used in studies related to bladder cancer biology and drug sensitivity. The cell line is part of panels like the Cancer Cell Line Encyclopedia (CCLE) and has been used in research on genetic diversity and ancestry in cancer cell lines.
Research Applications
Cancer biology researchDrug sensitivity profilingGenetic diversity studiesTumor heterogeneity analysis
Key Characteristics
Morphological heterogeneity in vitroTumorigenicity in nude miceTERT promoter mutationsPart of CCLE panel
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2081 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Ascites[UBERON:UBERON_0007795] |
Donor Information
| Age | 75 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Bladder carcinoma |
|---|---|
| Lineage | Bladder/Urinary Tract |
| Subtype | Bladder Urothelial Carcinoma |
| OncoTree Code | BLCA |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000753_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg280Thr (c.839G>C) | Heterozygous | - | Unknown, PubMed=12872257 |
| MutationSimple | TERT | c.1-124C>T (c.228C>T) (C228T) | Unspecified | In promoter | from parent cell line Hep-G2 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
8
D16S539
9,11
D18S51
15
D19S433
13,14
D21S11
29,31
D2S1338
17,24
D3S1358
15,16
D5S818
11
D7S820
8
D8S1179
16
FGA
23,24
Penta D
9
Penta E
12
TH01
6,9
TPOX
8
vWA
14,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Bladder Cancer 4:169-183(2018).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Identification of mutations in distinct regions of p85 alpha in urothelial cancer.
Knowles M.A.
PLoS ONE 8:E84411-E84411(2013).
Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine.
Hurst C.D., Platt F.M., Knowles M.A.
Eur. Urol. 65:367-369(2014).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).