JURL-MK1Homo sapiens (Human)Cancer cell line

Also known as: JURLMK1

🤖 AI SummaryBased on 6 publications

Quick Overview

JURL-MK1 is a human cell line derived from chronic myelogenous leukemia (CML) with unique characteristics in megakaryoblast dif...

Detailed Summary

JURL-MK1 is a human cell line established from the peripheral blood of a patient with chronic myelogenous leukemia (CML) in the blast crisis phase. It exhibits characteristics of megakaryoblasts, including the expression of specific surface markers such as CD33, CD63, and CD43, and lacks CD34 expression. The cell line is notable for its sensitivity to stem cell factor (SCF) and its ability to differentiate in response to agents like TPA and DMSO. JURL-MK1 is used in research to study megakaryocytopoiesis and the biological mechanisms of CML, particularly in the context of drug response and differentiation. Its unique properties make it a valuable model for investigating the role of c-kit (CD117) and other receptors in leukemia progression.

Research Applications

Megakaryocytopoiesis researchDrug sensitivity profilingDifferentiation studiesCancer cell line modeling

Key Characteristics

Expresses CD33, CD63, CD43Lacks CD34 expressionSensitive to SCFResponds to TPA and DMSO for differentiation

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2086
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	73
Age Category	Adult
Sex	Male
Subtype Features	BCR-ABL1 positive

Disease Information

Disease	Chronic myeloid leukemia
Lineage	Myeloid
Subtype	Chronic Myeloid Leukemia, BCR-ABL1+
OncoTree Code	CMLBCRABL1

DepMap Information

Source Type	DSMZ
Source ID	ACH-000326_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg306Ter (c.916C>T)	Heterozygous	Germline	PubMed=16418264
MutationSimple	KMT2D	p.Tyr1495Ter (c.4485C>A)	Homozygous	-	Unknown, Unknown
Gene fusion	ABL1	BCR-ABL1, BCR-ABL	-	BCR exon 1 fused to ABL1 exon 2	PubMed=10576511, PubMed=10071072, PubMed=8751477

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

D16S539

11,12

D18S51

D19S433

12,14

D21S11

27,29

D2S1338

17,23

D3S1358

15,17

D5S818

D7S820

10,13

D8S1179

FGA

21,23

Penta D

11,12

Penta E

14,16

TH01

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

DOI PubMed

ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";

Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.

Leuk. Res. 23:1055-1060(1999).

DOI PubMed

Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.

Drexler H.G., MacLeod R.A.F., Uphoff C.C.

Leuk. Res. 23:207-215(1999).

DOI PubMed

JURL-MK1 (c-kit(high)/CD30-/CD40-) and JURL-MK2 (c-kit(low)/CD30+/CD40+) cell lines: 'two-sided' model for investigating leukemic megakaryocytopoiesis.

Rotoli B., Del Vecchio L.

Leukemia 11:1554-1564(1997).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI