KCI-MOH1Homo sapiens (Human)Cancer cell line

Also known as: WSU-MOH1, KCIMOH1, KciMoh-1

🤖 AI SummaryBased on 7 publications

Quick Overview

Pancreatic ductal cell line with metabolic subtypes and drug sensitivity profiles.

Detailed Summary

KCI-MOH1 is a human pancreatic ductal cell line derived from a 74-year-old African American male patient with pancreatic cancer. It exhibits distinct metabolic subtypes, including glycolytic and lipogenic profiles, and shows differential sensitivity to metabolic inhibitors. The cell line has been characterized for its genetic and molecular features, including p53 and p21 expression, and has been used in preclinical studies to evaluate therapeutic agents such as gemcitabine, Ara-C, and Bryostatin 1. It is maintained in SCID mice and has a tumor take rate of 100% with a doubling time of 8.5 days. The cell line is valuable for studying pancreatic cancer biology and drug response.

Research Applications

Metabolic profiling and drug sensitivity testingPreclinical evaluation of therapeutic agentsMolecular and genetic characterization

Key Characteristics

Distinct metabolic subtypes (glycolytic and lipogenic)Expression of p53 and p21100% tumor take rate in SCID miceDoubling time of 8.5 days

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2090
Species	Homo sapiens (Human)
Tissue Source	Pancreas[UBERON:UBERON_0001264]

Donor Information

Age	64
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Pancreatic adenocarcinoma
Lineage	Pancreas
Subtype	Pancreatic Adenocarcinoma
OncoTree Code	PAAD

DepMap Information

Source Type	DSMZ
Source ID	ACH-001098_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	KRAS	p.Gly12Asp (c.35G>A)	Unspecified	-	PubMed=29786757
MutationSimple	CDKN2A	p.Glu120Ter (c.358G>T)	Unspecified	-	from parent cell line KYSE-30

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

9,10

D18S51

D19S433

D21S11

D2S1338

19,23

D3S1358

15,17

D5S818

D7S820

10,12

D8S1179

12,14

FGA

Penta D

Penta E

TH01

9.3

TPOX

10,11

vWA

15,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.

Manning G., Settleman J., Hatzivassiliou G., Evangelista M.

Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015).

DOI PubMed PMC

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Check your cultures! A list of cross-contaminated or misidentified cell lines.

Freshney R.I.

Int. J. Cancer 127:1-8(2010).

DOI PubMed

Synergistic effects of interferon-alpha in combination with chemoradiation on human pancreatic adenocarcinoma.

Marten A.

World J. Gastroenterol. 11:1521-1528(2005).

DOI PubMed PMC

Establishment of a human pancreatic tumor xenograft model: potential application for preclinical evaluation of novel therapeutic agents.

Sarkar F.H.

Pancreas 16:19-25(1998).

DOI PubMed

Web Resources

iclac.org