KellyHomo sapiens (Human)Cancer cell line

Also known as: NB19-RIKEN, NB-19, NB19, KELLY

🤖 AI SummaryBased on 12 publications

Quick Overview

Human neuroblastoma cell line for cancer research

Detailed Summary

The Kelly cell line is a human neuroblastoma cell line derived from a pediatric tumor. It is widely used in research to study the molecular mechanisms of neuroblastoma, particularly focusing on genetic alterations such as MYCN amplification. This cell line has been characterized in multiple studies for its utility in understanding tumor biology, drug sensitivity, and genetic profiling. Its applications include investigating oncogenic pathways, therapeutic target identification, and the development of targeted therapies. The Kelly cell line is part of a panel of neuroblastoma cell lines used in comprehensive genomic and transcriptomic analyses to identify biomarkers and potential treatment strategies.

Research Applications

Genomic and transcriptomic profilingMYCN amplification studiesOncogenic pathway investigationDrug sensitivity and resistance analysisTherapeutic target identification

Key Characteristics

MYCN amplificationNeuroblastoma originUsed in cancer researchPart of large cell line panels

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2092
Species	Homo sapiens (Human)
Tissue Source	Brain[UBERON:UBERON_0000955]

Donor Information

Age	1
Age Category	Pediatric
Sex	Female
Subtype Features	MYC_Amplified

Disease Information

Disease	Neuroblastoma
Lineage	Peripheral Nervous System
Subtype	Neuroblastoma
OncoTree Code	NBL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000259_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Pro177Thr (c.529C>A)	Homozygous	-	Unknown, Unknown
MutationSimple	ALK	p.Phe1174Leu (c.3522C>A)	Unspecified	Only detected in 5% of the cells in early passages but increase to 50% in late passages	from parent cell line SH-EP007

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D10S1248

13,14

D12S391

19,20

D13S317

10,14

D16S539

12,13

D18S51

14,17

D19S433

12,15.2

D1S1656

11,13

D21S11

28,30

D22S1045

D2S1338

17,20

D2S441

10,14

D3S1358

14,16

D5S818

11,13

D7S820

D8S1179

FGA

20,21

Penta D

9,14

Penta E

12,16

TH01

9.3

TPOX

8,10

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity.

Henssen A.G., Schwarz R.F., Haase K.

Cell Rep. 43:114711.1-114711.19(2024).

DOI PubMed

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Single-cell gene network analysis and transcriptional landscape of MYCN-amplified neuroblastoma cell lines.

Giorgi F.M.

Biomolecules 11:177.1-177.18(2021).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.

Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.

Sci. Data 4:170033-170033(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.

Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.

Transl. Oncol. 6:685-696(2013).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Oncogenic mutations of ALK kinase in neuroblastoma.";

Hayashi Y., Mano H., Ogawa S.

Nature 455:971-974(2008).

DOI PubMed

Identification of ALK as a major familial neuroblastoma predisposition gene.

Maris J.M.

Nature 455:930-935(2008).

DOI PubMed PMC

Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines.

Hayashi Y.

J. Pediatr. Surg. 42:2040-2045(2007).

DOI PubMed

1H MRS identifies specific metabolite profiles associated with MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell lines.

Edwards E.C., Strachan M.C., McMullan D.J., Wilkes T.M., Grundy R.G.

NMR Biomed. 20:692-700(2007).

DOI PubMed

Immunocytochemical analysis of cell lines derived from solid tumors.

Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.

J. Histochem. Cytochem. 49:1369-1378(2001).

DOI PubMed

Frequency of radiation-induced micronuclei in neuronal cells does not correlate with clonogenic survival.

Akudugu J.M., Slabbert J.P., Serafin A.M., Bohm L.

Radiat. Res. 153:62-67(2000).

DOI PubMed

Abnormalities of chromosome 1p in human neuroblastoma tumors and cell lines.

Schlesinger H.R.

Cancer Genet. Cytogenet. 7:33-42(1982).

DOI PubMed

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.

Gilbert F., Brodeur G.M., Goldstein M.N., Trent J.M.

Nature 305:245-248(1983).

DOI PubMed

Neuronal cell differentiation of human neuroblastoma cells by retinoic acid plus herbimycin A.

Preis P.N., Saya H., Nadasdi L., Hochhaus G., Levin V.A., Sadee W.

Cancer Res. 48:6530-6534(1988).

PubMed

Neuroblastoma.";

Thiele C.J.

(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999).

DOI