Ki-JKHomo sapiens (Human)Cancer cell line

Also known as: KIJK, KI-JK

🤖 AI SummaryBased on 5 publications

Quick Overview

Human anaplastic large cell lymphoma cell line with EBV expression

Detailed Summary

The Ki-JK cell line is a human anaplastic large cell lymphoma cell line established from a 15-year-old male patient with Ki-1-positive lymphoma. This cell line expresses the Ki-1 (CD30) antigen and Epstein-Barr virus (EBV) antigens, including EBV-associated nuclear antigen-2 (EBNA-2) and latent membrane protein (LMP). Ki-JK cells show tumorigenicity when injected into nude mice, forming tumors that express Ki-1 antigen. The cell line also demonstrates EBV BamHI W sequence presence in its DNA, as confirmed by polymerase chain reaction (PCR). These characteristics suggest a potential role for EBV in the pathogenesis of Ki-1-positive lymphomas. Ki-JK cells are useful for studying the mechanisms of EBV-related lymphomagenesis and for investigating the biological properties of anaplastic large cell lymphomas.

Research Applications

EBV-related lymphomagenesis studiesAnaplastic large cell lymphoma modelingEBV antigen expression analysis

Key Characteristics

Ki-1 (CD30) antigen positiveEBV antigen positive (EBNA-2, LMP)Tumorigenic in nude miceEBV BamHI W sequence presence

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2093
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age	15
Age Category	Pediatric
Sex	Male

Disease Information

Disease	ALK-positive anaplastic large cell lymphoma
Lineage	Lymphoid
Subtype	Anaplastic Large-Cell Lymphoma ALK Positive
OncoTree Code	ALCLALKP

DepMap Information

Source Type	HSRRB
Source ID	ACH-000773_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
Gene fusion	ALK	NPM1-ALK	-	-	PubMed=9121481, PubMed=7824924

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

12,13

D13S317

9,12

D16S539

D18S51

D19S433

12,14

D21S11

D2S1338

19,20

D3S1358

17,18

D5S818

11,12

D7S820

10,12

D8S1179

FGA

20,28

Penta D

Penta E

TH01

8,9

TPOX

10,11

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.

O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.

J. Virol. 89:713-729(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Malignant hematopoietic cell lines: in vitro models for the study of anaplastic large-cell lymphoma.

Drexler H.G., MacLeod R.A.F.

Leukemia 18:1569-1571(2004).

DOI PubMed

PTEN gene alterations in lymphoid neoplasms.";

Sakai A., Thieblemont C., Wellmann A., Jaffe E.S., Raffeld M.

Blood 92:3410-3415(1998).

DOI PubMed

The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.

Quentmeier H., Drexler H.G.

Leukemia 10:142-149(1996).

PubMed

A Ki-1-positive cell line expressing Epstein-Barr virus antigens, established from a child with Ki-1-positive lymphoma.

Inoue H., Yutsudo M., Hakura A., Ikegami N.

Intervirology 36:215-224(1993).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI