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L-1236Homo sapiens (Human)Cancer cell line

Also known as: L 1236, L1236

🤖 AI SummaryBased on 8 publications

Quick Overview

Human cell line derived from Hodgkin lymphoma, used in cancer research.

Detailed Summary

The L-1236 cell line is a human-derived cell line established from Hodgkin lymphoma tissue. It is utilized in cancer research to study the molecular mechanisms and therapeutic responses of Hodgkin lymphoma. This cell line has been characterized in multiple studies, including analyses of genetic mutations and their implications in disease progression. Research involving L-1236 has contributed to understanding the role of specific genes and pathways in lymphoma development and treatment resistance. The cell line is part of several comprehensive cell line databases and has been used in studies related to drug sensitivity and molecular profiling.

Research Applications

Cancer researchMolecular profilingDrug sensitivity studies

Key Characteristics

Used in studies of Hodgkin lymphomaPart of comprehensive cell line databasesCharacterized for genetic mutations

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2096
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	34
Age Category	Adult
Sex	Male

Disease Information

Disease	Hodgkin lymphoma
Lineage	Lymphoid
Subtype	Hodgkin Lymphoma
OncoTree Code	HL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000702_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationUnexplicit	TP53	Fusion of Ex9 wiith an Alu-element	Unspecified	-	PubMed=17065008
MutationSimple	TNFAIP3	p.Trp142Ter (c.425G>A) (G491A)	Heterozygous	-	PubMed=19380639
Gene deletion	TNFAIP3	-	Heterozygous	-	PubMed=19380639

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,14

D13S317

13

D16S539

9,13

D18S51

15,19

D19S433

14,17

D21S11

27

D2S1338

18

D3S1358

15,16

D5S818

11,13

D7S820

9,10

D8S1179

12,13

FGA

21,25

Penta D

10

Penta E

7,10

TH01

6

TPOX

8,12

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

Hodgkin lymphoma cell lines: to separate the wheat from the chaff.";

Drexler H.G., Pommerenke C., Eberth S., Nagel S.

Biol. Chem. 399:511-523(2018).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.

O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.

J. Virol. 89:713-729(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.

Kutok J.L., Shipp M.A.

Blood 116:3268-3277(2010).

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.

Stanelle J., Siebert R., Kuppers R.

J. Exp. Med. 206:981-989(2009).

Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma.

Sturzenhofecker B., Kube D.

Leuk. Lymphoma 47:1932-1940(2006).

Profiling of Hodgkin's lymphoma cell line L1236 and germinal center B cells: identification of Hodgkin's lymphoma-specific genes.

Hansmann M.-L., Rajewsky K., Kuppers R.

Mol. Med. 9:85-95(2003).

Peripheral blood mononuclear cells of a patient with advanced Hodgkin's lymphoma give rise to permanently growing Hodgkin-Reed Sternberg cells.

Diehl V.

Blood 87:3418-3428(1996).

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).