LOU-NH91Homo sapiens (Human)Cancer cell line

Also known as: LouNH91, LOUNH91, LOU-NH-91

🤖 AI SummaryBased on 9 publications

Quick Overview

Human cancer cell line with unknown tissue and disease origin.

Detailed Summary

LOU-NH91 is a human cancer cell line with unknown tissue and disease origin. The cell line is part of a comprehensive study of cancer cell lines, which includes analysis of gene expression, chromosomal copy number, and somatic mutations. Research on this cell line has contributed to understanding the genetic and molecular mechanisms underlying cancer development and drug sensitivity. The cell line is used in studies related to cancer biology, drug discovery, and personalized medicine.
Generated on 6/18/2025

Basic Information

Database IDCVCL_2104
SpeciesHomo sapiens (Human)
Tissue SourceLung, right lower lobe[UBERON:UBERON_0002171]

Donor Information

Age64
Age CategoryAdult
SexFemale

Disease Information

DiseaseLung squamous cell carcinoma
LineageLung
SubtypeLung Squamous Cell Carcinoma
OncoTree CodeLUSC

DepMap Information

Source TypeDSMZ
Source IDACH-000176_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Val143Met (c.427G>A)Heterozygous-Unknown, Unknown
MutationSimplePIK3CAp.Glu726Lys (c.2176G>A)Unspecified-PubMed=34663790
MutationSimpleNF2p.Pro257Argfs*39 (c.770del) (p.Phe256fs)Heterozygous-Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
10,12
D13S317
12
D16S539
13
D18S51
12
D19S433
14
D21S11
30
D2S1338
25
D3S1358
17
D5S818
12,13
D7S820
10,11
D8S1179
11
FGA
21
Penta D
15
Penta E
5
TH01
9.3
TPOX
11
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Comparative proteome analysis across non-small cell lung cancer cell lines.

Daub H.

J. Proteomics 130:1-10(2016).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.

Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.

Br. J. Cancer 109:1599-1608(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.

Zhou X.-M., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.

Cell 131:1190-1203(2007).

Near-haploid karyotype in a squamous cell lung carcinoma.";

Drouin V., Viguie F., Debesse B.

Genes Chromosomes Cancer 7:209-212(1993).