M-07eHomo sapiens (Human)Cancer cell line

Also known as: MO7E, M07E, MO7e, Mo7e, M07e, M07-e, M-O7e, M-07E

🤖 AI SummaryBased on 7 publications

Quick Overview

M-07e is a human cell line derived from acute megakaryoblastic leukemia, characterized by the presence of the JAK2 V617F mutati...

Detailed Summary

M-07e is a human cell line established from a patient with acute megakaryoblastic leukemia (AML M7). It is notable for harboring the JAK2 V617F mutation, which is associated with myeloproliferative disorders. This cell line exhibits specific surface markers such as CD41, CD42, and CD61, which are indicative of megakaryocytic differentiation. Research on M-07e has focused on understanding the role of the JAK2 V617F mutation in leukemogenesis and drug sensitivity. The cell line is also used to study the effects of thrombopoietin (TPO) on cell growth and differentiation. Additionally, M-07e has been utilized in studies examining the genetic and molecular characteristics of myeloid malignancies, including copy number alterations and gene expression profiles.

Research Applications

Study of JAK2 V617F mutation in myeloproliferative disordersInvestigation of thrombopoietin (TPO) effects on cell growth and differentiationAnalysis of surface markers for megakaryocytic differentiationEvaluation of drug sensitivity and resistance mechanismsGenomic and molecular profiling of myeloid malignancies

Key Characteristics

Presence of JAK2 V617F mutationExpression of megakaryocytic surface markers (CD41, CD42, CD61)Sensitivity to thrombopoietin (TPO)Use in studying myeloid leukemia pathogenesis

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2106
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age Category	Pediatric
Sex	Female

Disease Information

Disease	Acute megakaryoblastic leukemia
Lineage	Myeloid
Subtype	Acute Megakaryoblastic Leukemia
OncoTree Code	AMKL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000602_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	NRAS	p.Gln61Lys (c.181C>A)	Unspecified	Acquired during resistance selection process	PubMed=26214590
Gene fusion	CBFA2T3	CBFA2T3-GLIS2, ETO2-GLIS2	-	-	PubMed=28109323
Gene fusion	ANO7	ANO7-DHDH	-	-	from parent cell line M-07e

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

9,10

D13S317

10,11

D16S539

D18S51

15,20

D19S433

14,15

D21S11

30,32.2

D2S1338

19,25

D3S1358

16,19

D5S818

D7S820

D8S1179

FGA

18,22

Penta D

Penta E

12,14

TH01

6,8

TPOX

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene.

Pigazzi M., Martelli A.M., Basso G., Locatelli F., Pession A.

J. Hematol. Oncol. 10:26.1-26.5(2017).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

DOI PubMed

Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.

Wolf E., Gabius H.-J.

J. Cancer Res. Clin. Oncol. 127:375-386(2001).

DOI PubMed

Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines.

Drexler H.G., Zaborski M., Quentmeier H.

Leukemia 11:541-551(1997).

DOI PubMed

M-07e human leukemic factor-dependent cell line provides a rapid and sensitive bioassay for the human cytokines GM-CSF and IL-3.

Pegoraro L., Clark S.C.

J. Cell. Physiol. 145:458-464(1990).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

cells-talk.com