MFE-319Homo sapiens (Human)Cancer cell line
Also known as: MFE319
🤖 AI SummaryBased on 4 publications
Quick Overview
Human cancer cell line with unknown tissue and disease origins.
Detailed Summary
MFE-319 is a human cancer cell line with unknown tissue and disease origins. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been characterized in terms of genetic and pharmacological profiles. The cell line is used in research to understand drug sensitivity and predictive modeling of anticancer treatments. However, specific details about its tissue of origin, disease type, and cell type are not available in the provided data. Further studies are needed to determine its exact characteristics and applications.
Research Applications
Drug sensitivity profilingPredictive modeling of anticancer treatments
Key Characteristics
Part of the Cancer Cell Line Encyclopedia (CCLE)Genetic and pharmacological profiling available
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2112 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Endometrium[UBERON:UBERON_0001295] |
Donor Information
| Age | 81 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Endometrial adenosquamous carcinoma |
|---|---|
| Lineage | Uterus |
| Subtype | Uterine Adenosquamous Carcinoma |
| OncoTree Code | UASC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000988_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg273Cys (c.817C>T) | Homozygous | - | PubMed=35933914 |
| MutationSimple | TP53 | p.Tyr220Cys (c.659A>G) | Unspecified | - | PubMed=21173094 |
| MutationSimple | ERBB3 | p.Trp902Ter (c.2706G>A) | Heterozygous | - | Unknown, Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,13
D13S317
13
D16S539
9,11
D18S51
13,16
D19S433
14,15
D21S11
28,30
D2S1338
20,25
D3S1358
14,16
D5S818
11,12
D7S820
8,8.1,12
D8S1179
15,16
FGA
20,21
Penta D
9,11
Penta E
18
TH01
8,9.3
TPOX
8,11
vWA
18,19,20
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).