MOLM-1Homo sapiens (Human)Cancer cell line

Also known as: MOLM1

🤖 AI SummaryBased on 7 publications

Quick Overview

MOLM-1 is a human leukemia cell line derived from myeloid lineage, commonly used in research on leukemogenesis and genetic muta...

Detailed Summary

MOLM-1 is a human leukemia cell line established from myeloid lineage, frequently utilized in studies related to leukemogenesis and genetic mutations. It is known for its expression of specific genetic alterations, including mutations in the cohesin complex and other key oncogenic pathways. Research on MOLM-1 has contributed to understanding the molecular mechanisms underlying myeloid malignancies, particularly in the context of chromosomal abnormalities and gene mutations. This cell line is valuable for investigating the role of specific genetic alterations in the development and progression of leukemia.

Research Applications

LeukemogenesisGenetic mutationsCohesin complex alterationsMyeloid malignancies

Key Characteristics

Expression of cohesin mutationsRelevance in myeloid leukemia research

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2118
Species	Homo sapiens (Human)
Tissue Source	Bone marrow[UBERON:UBERON_0002371]

Donor Information

Age	41
Age Category	Adult
Sex	Male

Disease Information

Disease	Chronic myeloid leukemia
Lineage	Myeloid
Subtype	Chronic Myeloid Leukemia, BCR-ABL1+
OncoTree Code	CMLBCRABL1

DepMap Information

Source Type	DSMZ
Source ID	ACH-001573_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg196Ter (c.586C>T)	Unspecified	-	PubMed=25275298
Gene fusion	ABL1	BCR-ABL1, BCR-ABL	-	BCR exon 1 fused to ABL1 exon 2	PubMed=10576511, PubMed=10071072, PubMed=8751477

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

8,12

D16S539

9,11

D18S51

D19S433

D21S11

30,31

D2S1338

17,24

D3S1358

16,17

D5S818

D7S820

D8S1179

10,12

FGA

23,24

Penta D

Penta E

14,19

TH01

7,9

TPOX

8,12

vWA

14,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.

Haferlach T., Shirahige K., Miyano S., Ogawa S.

Nat. Genet. 45:1232-1237(2013).

DOI PubMed

FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.

Tsuchida M., Sugita K., Ida K., Hayashi Y.

Blood 103:1085-1088(2004).

DOI PubMed

Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 25:275-278(2001).

DOI PubMed

Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 24:255-262(2000).

DOI PubMed

Efficient DNA fingerprinting method for the identification of cross-culture contamination of cell lines.

Matsuo Y., Nishizaki C., Drexler H.G.

Hum. Cell 12:149-154(1999).

PubMed

ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";

Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.

Leuk. Res. 23:1055-1060(1999).

DOI PubMed

Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.

Drexler H.G., MacLeod R.A.F., Uphoff C.C.

Leuk. Res. 23:207-215(1999).

DOI PubMed

Frameshift mutations of the hMSH6 gene in human leukemia cell lines.

Hirai H.

Jpn. J. Cancer Res. 89:33-39(1998).

DOI PubMed PMC

Establishment and characterization of a novel megakaryoblastic cell line, MOLM-1, from a patient with chronic myelogenous leukemia.

Matsuo Y., Adachi T., Tsubota T., Imanishi J., Minowada J.

Hum. Cell 4:261-264(1991).

PubMed

Identification of cell lines with variable numbers of tandem repeat (VNTR) amplified by polymerase chain reaction.

Matsuo Y., Okochi A., Ariyasu T., Iimura E., Ohno T.

Tissue Cult. Res. Commun. 15:211-219(1996).

DOI

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI