MOLM-16Homo sapiens (Human)Cancer cell line

Also known as: MOLM16

🤖 AI SummaryBased on 6 publications

Quick Overview

MOLM-16 is a megakaryoblastic leukemia cell line derived from a patient with AML-M0, characterized by myeloid/NK precursor phen...

Detailed Summary

MOLM-16 is a megakaryoblastic leukemia cell line established from the peripheral blood of a 77-year-old Japanese woman with minimally differentiated acute myeloid leukemia (AML-M0). It exhibits a myeloid/NK precursor phenotype, being positive for CD7, CD13, CD33, CD34, and CD56. The cell line is responsive to various cytokines such as EPO, GM-CSF, IL-5, PIXY-321, and TPO. MOLM-16 displays megakaryocytic lineage characteristics with positive expression of CD7, CD33, CD61, CD46, CD62, CD63, CD110, CD151, thrombospondin, von Willebrand factor (vWF), and fibrinogen. Cytogenetic analysis revealed complex abnormalities including t(6;8)(q21;q24.3) and t(9;18)(q13;q21). The cell line is free from mycoplasma and EBV infection, and has been maintained in culture for over 12 months with a doubling time of 4-5 days. It is used in research for understanding megakaryocytic differentiation and leukemia biology.

Research Applications

Leukemia researchMegakaryocytic differentiation studiesCytokine response analysisCytogenetic and molecular characterization

Key Characteristics

Myeloid/NK precursor phenotypeCytokine responsivenessMegakaryocytic lineage markersComplex chromosomal abnormalities

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2120
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	77
Age Category	Adult
Sex	Female
Race	asian

Disease Information

Disease	Acute myeloid leukemia
Lineage	Myeloid
Subtype	Acute Myeloid Leukemia
OncoTree Code	AML

DepMap Information

Source Type	DSMZ
Source ID	ACH-000369_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Cys238Ser (c.713G>C)	Heterozygous	-	Unknown
MutationSimple	TP53	p.Val173Met (c.517G>A)	Unspecified	-	PubMed=11107048, PubMed=1933850, PubMed=1370612

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

9,12

D16S539

D18S51

15,23

D19S433

D21S11

D2S1338

23,24

D3S1358

D5S818

D7S820

11,12

D8S1179

13,14

FGA

Penta D

Penta E

13,20

TH01

TPOX

8,11

vWA

15,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

DOI PubMed

Megakaryoblastic leukemia cell line MOLM-16 derived from minimally differentiated acute leukemia with myeloid/NK precursor phenotype.

Yasukawa M., Tanimoto M., Orita K.

Leuk. Res. 27:165-171(2003).

DOI PubMed