MOLM-6Homo sapiens (Human)Cancer cell line
Also known as: MOLM6
🤖 AI SummaryBased on 4 publications
Quick Overview
MOLM-6 is a human leukemia cell line derived from chronic myeloid leukemia in blast crisis.
Detailed Summary
MOLM-6 is a human leukemia cell line established from a patient with chronic myeloid leukemia (CML) in blast crisis. It is widely used in cancer research for studying the molecular mechanisms of leukemia and for drug screening. The cell line is characterized by specific genetic alterations, including mutations in the p53 gene, which are critical for understanding tumor progression and therapeutic resistance. MOLM-6 provides a valuable model for investigating the biology of CML and developing targeted therapies.
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2122 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age | 44 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Subtype Features | BCR-ABL1 positive |
Disease Information
| Disease | Chronic myeloid leukemia |
|---|---|
| Lineage | Myeloid |
| Subtype | Chronic Myeloid Leukemia, BCR-ABL1+ |
| OncoTree Code | CMLBCRABL1 |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000321_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene fusion | ABL1 | BCR-ABL1, BCR-ABL | - | BCR exon 1 fused to ABL1 exon 2 | PubMed=10576511, PubMed=10071072, PubMed=8751477 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11,12
D13S317
11,13
D16S539
10,11
D18S51
15
D19S433
13,14
D21S11
30.2,33.2
D2S1338
18,23
D3S1358
15
D5S818
10,12
D7S820
10
D8S1179
10
FGA
21,26
Penta D
9
Penta E
5,16
TH01
9
TPOX
8
vWA
16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Screening human cell lines for viral infections applying RNA-Seq data analysis.
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
PLoS ONE 14:E0210404-E0210404(2019).
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
Yang H.H., Koeffler H.P.
BMC Cancer 18:940.1-940.13(2018).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
p53 alterations in human leukemia-lymphoma cell lines: in vitro artifact or prerequisite for cell immortalization?
Uphoff C.C.
Leukemia 14:198-206(2000).
Establishment of multiple leukemia cell lines with diverse myeloid and/or megakaryoblastoid characteristics from a single Ph1 positive chronic myelogenous leukemia blood sample.
Tsubota T., Imanishi J., Minowada J.
Hum. Cell 7:167-171(1994).