MOLP-8Homo sapiens (Human)Cancer cell line

Also known as: MOLP8

🤖 AI SummaryBased on 7 publications

Quick Overview

MOLP-8 is a human multiple myeloma cell line with t(11;14) translocation, used for studying myeloma biology and drug responses.

Detailed Summary

MOLP-8 is a human multiple myeloma cell line established from the peripheral blood of a 52-year-old Japanese male patient with stage IIIA bone marrow disease. It carries the t(11;14)(q13;q32) chromosomal translocation and expresses δ/λ type immunoglobulin. The cell line is characterized by its ability to grow independently of exogenous growth factors and exhibits a plasma cell morphology with abundant cytoplasm and heterogeneous cell size. MOLP-8 is notable for its lack of CD28 expression, which is typically present in other myeloma cell lines. This cell line has been used in studies investigating the role of CD28 in myeloma cell adhesion and signaling, as well as in the development of in vivo models for myeloma research. Its unique genetic and phenotypic profile makes it a valuable tool for understanding the molecular mechanisms underlying multiple myeloma.

Research Applications

Study of myeloma biologyInvestigation of CD28 expression and functionDrug response profilingIn vivo modeling of myelomaAnalysis of chromosomal translocations

Key Characteristics

t(11;14)(q13;q32) translocationδ/λ type immunoglobulin expressionIndependence from exogenous growth factorsPlasma cell morphologyLack of CD28 expression

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2124
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	52
Age Category	Adult
Sex	Male
Race	asian

Disease Information

Disease	Multiple myeloma
Lineage	Lymphoid
Subtype	Plasma Cell Myeloma
OncoTree Code	PCM

DepMap Information

Source Type	DSMZ
Source ID	ACH-000745_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	NRAS	p.Gln61Leu (c.182A>T)	Unspecified	-	PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

11,12

D16S539

10,11

D18S51

15,16

D19S433

D21S11

29,30

D2S1338

19,23

D3S1358

12,15

D5S818

D7S820

7,8

D8S1179

11,13

FGA

21,25

Penta D

Penta E

TH01

TPOX

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.

Sirota M., Wiita A.P.

Leukemia 34:2754-2765(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Induction of CD28 on the new myeloma cell line MOLP-8 with t(11;14)(q13;q32) expressing delta/lambda type immunoglobulin.

Kojima K., Orita K.

Leuk. Res. 28:869-877(2004).

DOI PubMed

Web Resources

keatslab.org tcpaportal.org