MUTZ-8Homo sapiens (Human)Cancer cell line
Also known as: Menschliche Und Tierische Zellkulture-8, MUTZ8
🤖 AI SummaryBased on 3 publications
Quick Overview
MUTZ-8 is a human AML cell line with 5q deletion and JAK2 mutation.
Detailed Summary
MUTZ-8 is a human acute myeloid leukemia (AML) cell line derived from a patient with a history of myelodysplastic syndrome (MDS). It is characterized by a specific chromosomal deletion of 5q31 and a JAK2 V617F mutation. This cell line exhibits cytokine dependency, requiring external growth factors for proliferation. It shows sensitivity to JAK2 inhibition, making it a valuable tool for studying the role of JAK2 mutations in myeloproliferative disorders. MUTZ-8 is also notable for its unique cytogenetic features, including a non-reciprocal translocation t(5,11)(q21,10), which contributes to its distinct genetic profile. The cell line's responsiveness to various cytokines and its genetic alterations make it a useful model for researching AML and MDS pathogenesis.
Research Applications
Study of JAK2 V617F mutation in myeloproliferative disordersInvestigation of 5q31 deletion in AML/MDSCytokine signaling and response profilingModel for JAK2 inhibitor sensitivity
Key Characteristics
Cytokine-dependent proliferationJAK2 V617F mutation5q31 deletionNon-reciprocal translocation t(5,11)(q21,10)Sensitivity to JAK2 inhibition
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2130 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age | 63 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Acute myeloid leukemia |
|---|---|
| Lineage | Myeloid |
| Subtype | Acute Myeloid Leukemia |
| OncoTree Code | AML |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001577_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | JAK2 | p.Val617Phe (c.1849G>T) | Homozygous | - | from parent cell line UKE-1 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
9,11
D16S539
12
D18S51
12,15
D19S433
13,15
D21S11
28,29
D2S1338
17,23
D3S1358
16
D5S818
12
D7S820
11
D8S1179
14
FGA
18,20
Penta D
13,15
Penta E
12,20
TH01
9,9.3
TPOX
8,9
vWA
18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
Leukemia 20:471-476(2006).
New acute myeloid leukemia-derived cell line: MUTZ-8 with 5q-.";
Hu Z.-B., MacLeod R.A.F., Meyer C., Quentmeier H., Drexler H.G.
Leukemia 16:1556-1561(2002).
Establishment of the two cytokine-dependent acute myeloid leukemia-derived cell lines MUTZ-8 and MUTZ-11.
Hu Z.-B., Quentmeier H., Meyer C., MacLeod R.A.F., Drexler H.G.
(In book chapter) Acute leukemias IX. Haematology and blood transfusion, Vol. 41; Hiddemann W., Haferlach T., Unterhalt M., Buechner T., Ritter J. (eds.); pp.122-127; Springer; Berlin; Germany (2003).