NGPHomo sapiens (Human)Cancer cell line

🤖 AI SummaryBased on 14 publications

Quick Overview

Human neuroblastoma cell line with MYCN amplification and NF1 mutations.

Detailed Summary

The NGP cell line is a human neuroblastoma cell line derived from a neuroblastoma tumor. It is characterized by MYCN amplification and mutations in the NF1 gene, which are associated with aggressive disease and poor prognosis. NGP cells are commonly used in research to study the molecular mechanisms of neuroblastoma progression and therapeutic resistance. The cell line has been utilized in studies examining the role of NF1 in retinoic acid response and tumor suppression, as well as in genomic analyses to identify chromosomal abnormalities and potential therapeutic targets. NGP is also used to investigate the impact of genetic alterations on cell behavior and response to treatment.

Research Applications

MYCN amplification analysisNF1 mutation studiesRetinoic acid response investigationGenomic profilingTherapeutic resistance research

Key Characteristics

MYCN amplificationNF1 mutationsAggressive tumor phenotypeHigh genomic instability

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2141
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	2
Age Category	Pediatric
Sex	Male
Subtype Features	MYC_Amplified

Disease Information

Disease	Neuroblastoma
Lineage	Peripheral Nervous System
Subtype	Neuroblastoma
OncoTree Code	NBL

DepMap Information

Source Type	DSMZ
Source ID	ACH-001366_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Cys141Trp (c.423C>G)	Unspecified	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,12

D13S317

8,12

D16S539

8,11

D18S51

D19S433

13,14

D21S11

32,33

D2S1338

24,25

D3S1358

D5S818

11,12

D7S820

D8S1179

FGA

19,23

Penta D

8,10

Penta E

11,15

TH01

TPOX

6,9

vWA

16,21

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.

Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.

Sci. Data 4:170033-170033(2017).

DOI PubMed PMC

Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.

Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.

Transl. Oncol. 6:685-696(2013).

DOI PubMed PMC

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.

Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.

Nat. Genet. 45:12-17(2013).

DOI PubMed PMC

PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.

Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.

Int. J. Cancer 131:1556-1568(2012).

DOI PubMed PMC

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.

Messiaen L.M., Versteeg R., Bernards R.

Cell 142:218-229(2010).

DOI PubMed PMC

Identification of ALK as a major familial neuroblastoma predisposition gene.

Maris J.M.

Nature 455:930-935(2008).

DOI PubMed PMC

Mutations in PIK3CA are infrequent in neuroblastoma.";

Dam V., Morgan B.T., Mazanek P., Hogarty M.D.

BMC Cancer 6:177.1-177.10(2006).

DOI PubMed PMC

High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.

Maris J.M.

Genes Chromosomes Cancer 43:390-403(2005).

DOI PubMed

Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.

Gabbert H.E., Poremba C.

Cancer Res. 64:3395-3405(2004).

DOI PubMed

Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.

Salwen H.R., Laureys G., Manoel N., De Paepe A., Speleman F.

Genes Chromosomes Cancer 32:126-135(2001).

DOI PubMed

Comparative genomic hybridization analysis of human neuroblastomas: detection of distal 1p deletions and further molecular genetic characterization of neuroblastoma cell lines.

De Paepe A., Cremer T., Speleman F.

Cancer Genet. Cytogenet. 97:135-142(1997).

DOI PubMed

Neurofibromatosis type 1 gene mutations in neuroblastoma.";

Gusella J.F., Bernards A.

Nat. Genet. 3:62-66(1993).

DOI PubMed

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.

Gilbert F., Brodeur G.M., Goldstein M.N., Trent J.M.

Nature 305:245-248(1983).

DOI PubMed

Chromosomal aberrations in human neuroblastomas.";

Brodeur G.M., Sekhon G.S., Goldstein M.N.

Cancer 40:2256-2263(1977).

DOI PubMed

Tumor cell lines of the peripheral nervous system.";

Israel M.A., Thiele C.J.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York; USA (1994).

DOI

Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.

Biedler J.L., Meyers M.B., Spengler B.A.

(In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff S., Hertz L. (eds.); pp.267-307; Academic Press; New York; USA (1983).

DOI

Neuroblastoma.";

Thiele C.J.

(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999).

DOI