OCI-M1Homo sapiens (Human)Cancer cell line

Also known as: OCIM1, OCI M1

🤖 AI SummaryBased on 4 publications

Quick Overview

Human cancer cell line with unknown tissue and disease origins.

Detailed Summary

OCI-M1 is a human cancer cell line with unknown tissue and disease origins. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for its genomic and transcriptomic features. The cell line has been used in studies related to cancer genomics, drug sensitivity, and molecular profiling. Research on OCI-M1 has contributed to understanding the genetic diversity and heterogeneity of cancer cell lines, which is crucial for developing targeted therapies and personalized medicine approaches.

Research Applications

Cancer genomicsDrug sensitivity profilingMolecular profiling

Key Characteristics

Part of the Cancer Cell Line Encyclopedia (CCLE)Used in studies of cancer genomic diversityContributed to understanding of cancer cell line heterogeneity

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2149
Species	Homo sapiens (Human)

Donor Information

Age	62
Age Category	Adult
Sex	Unknown

Disease Information

Disease	Acute myeloid leukemia
Lineage	Myeloid
Subtype	Acute Myeloid Leukemia
OncoTree Code	AML

DepMap Information

Source Type	DSMZ
Source ID	ACH-000751_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	c.673-2A>T (IVS6-2A>T)	Unspecified	Splice acceptor mutation	PubMed=11799138
MutationSimple	TP53	p.Leu145Arg (c.434T>G)	Homozygous	-	from parent cell line SK-MEL-28

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12,14

D13S317

11,12

D16S539

D18S51

D19S433

15,16

D21S11

31.2,33.2

D2S1338

18,24

D3S1358

17,18

D5S818

D7S820

D8S1179

FGA

18,24

Penta D

6,11

Penta E

10,11

TH01

TPOX

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Surface antigenic profile and globin phenotype of two new human erythroleukemia lines: characterization and interpretations.

Messner H.A.

Blood 72:1029-1038(1988).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI