PL-21Homo sapiens (Human)Cancer cell line

Also known as: PL21

🤖 AI SummaryBased on 1 publications

Quick Overview

PL-21 is a human cell line with FLT3 mutations, used in leukemia research.

Detailed Summary

PL-21 is a human cell line derived from acute myeloid leukemia (AML) and is characterized by the presence of FLT3 internal tandem duplications (ITD). These mutations are associated with constitutive activation of the FLT3 receptor, which plays a critical role in cell proliferation and survival. Research on PL-21 has contributed to understanding the signaling pathways involved in FLT3-driven leukemias, including the activation of STAT-5 and the response to kinase inhibitors. The cell line is also notable for its use in studying the differences between wild-type and mutant FLT3 receptor signaling. PL-21 is part of a panel of AML-derived cell lines that have been screened for FLT3 mutations, providing insights into the molecular mechanisms of AML and potential therapeutic targets.

Research Applications

FLT3 mutation analysisLeukemia researchSignal transduction studiesKinase inhibitor testing

Key Characteristics

FLT3 internal tandem duplication (ITD)Constitutive FLT3 receptor activationSTAT-5 phosphorylationAML-derived cell line

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2161
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	24
Age Category	Adult
Sex	Male

Disease Information

Disease	Acute myeloid leukemia
Lineage	Myeloid
Subtype	Acute Myeloid Leukemia
OncoTree Code	AML

DepMap Information

Source Type	DSMZ
Source ID	ACH-000218_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Pro36fs*8 (c.107delC)	Heterozygous	-	Unknown
MutationSimple	KRAS	p.Ala146Val (c.437C>T)	Unspecified	-	PubMed=20570890
MutationUnexplicit	FLT3	Internal tandem duplication (FLT3-ITD)	Unspecified	-	PubMed=12529668

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,12

D13S317

8,11

D16S539

11,13

D18S51

12,13

D19S433

13,14

D21S11

29,30

D2S1338

23,27

D3S1358

D5S818

D7S820

12,13

D8S1179

FGA

21,24

Penta D

11,13

Penta E

5,17

TH01

TPOX

9,11

vWA

14,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

FLT3 mutations in acute myeloid leukemia cell lines.";

Quentmeier H., Reinhardt J., Zaborski M., Drexler H.G.

Leukemia 17:120-124(2003).

DOI PubMed

Two new human myeloid cell lines derived from acute promyelocytic leukemia and chronic myelocytic leukemia.

Miyoshi I.

Gann 74:319-322(1983).

DOI PubMed

Establishment of a new peroxidase-positive human myeloid cell line, PL-21.

Miyoshi I.

Blood 63:254-259(1984).

DOI PubMed

Frequent mutations in the p53 gene in human myeloid leukemia cell lines.

Ishikawa F., Takaku F., Yazaki Y., Hirai H.

Blood 79:2378-2383(1992).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI