Rh41Homo sapiens (Human)Cancer cell line

Also known as: SJ-Rh41, Rh-41, RH-41, RH41

🤖 AI SummaryBased on 11 publications

Quick Overview

Rh41 is a human rhabdomyosarcoma cell line used in cancer research.

Detailed Summary

Rh41 is a human rhabdomyosarcoma cell line derived from a lung metastasis in a 7-year-old female. It is classified as an alveolar rhabdomyosarcoma (ARMS) and is characterized by the presence of PAX-FKHR fusion transcripts. This cell line is commonly used in studies related to sarcoma biology, drug screening, and molecular profiling. Rh41 has been utilized in research to investigate the effects of various anticancer agents and to understand the genetic and molecular mechanisms underlying rhabdomyosarcoma progression. It is part of a panel of cell lines used for in vitro cytotoxicity testing and has been involved in studies examining gene expression profiles and therapeutic responses.

Research Applications

Sarcoma biologyDrug screeningMolecular profilingIn vitro cytotoxicity testing

Key Characteristics

PAX-FKHR fusion transcriptsAlveolar rhabdomyosarcoma subtypeLung metastasis origin

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2176
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	7
Age Category	Pediatric
Sex	Female

Disease Information

Disease	Alveolar rhabdomyosarcoma
Lineage	Soft Tissue
Subtype	Alveolar Rhabdomyosarcoma
OncoTree Code	ARMS

DepMap Information

Source Type	DSMZ
Source ID	ACH-000100_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
Gene fusion	FOXO1	PAX3-FOXO1, PAX3-FKHR	-	Not found in original tumor	from parent cell line Rh30

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,12

D13S317

8,9

D16S539

12,13

D18S51

15,16

D19S433

13,15

D21S11

29,31

D2S1338

17,21

D3S1358

D5S818

10,13

D7S820

10,11

D8S1179

10,13

FGA

20,22

Penta D

9,12

Penta E

11,17

TH01

7,9.3

TPOX

8,11

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Assessing alveolar rhabdomyosarcoma cell lines as tumor models by comparison of mRNA expression profiles.

Batchu S., Kellish A.S., Hakim A.A.

Gene 760:145025.1-145025.5(2020).

DOI PubMed

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Proteomic profiling of rhabdomyosarcoma-derived exosomes yield insights into their functional role in paracrine signaling.

Diab-Assaf M., Saab R., Ghayad S.E.

J. Proteome Res. 18:3567-3579(2019).

DOI PubMed

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.

Harris E., Monks A., Morris J.

Mol. Cancer Ther. 14:2452-2462(2015).

DOI PubMed PMC

Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research: utility and pitfalls.

Linardic C.M.

Front. Oncol. 3:183.1-183.12(2013).

DOI PubMed PMC

Proof-of-concept rare cancers in drug development: the case for rhabdomyosarcoma.

Sokolowski E., Turina C.B., Kikuchi K., Langenau D.M., Keller C.

Oncogene 33:1877-1889(2014).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways.

Borsu L., Barr F.G., Ladanyi M.

Clin. Cancer Res. 18:748-757(2012).

DOI PubMed PMC

National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.

Reynolds C.P.

Pediatr. Blood Cancer 56:239-249(2011).

DOI PubMed PMC

Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: an approach to identify candidate genes involved in tumor development.

Pritchard-Jones K., Kool M., Shipley J.M.

Genes Chromosomes Cancer 48:455-467(2009).

DOI PubMed

Global gene expression profiling of PAX-FKHR fusion-positive alveolar and PAX-FKHR fusion-negative embryonal rhabdomyosarcomas.

Olshen A.B., Barr F.G., Ladanyi M.

J. Pathol. 212:143-151(2007).

DOI PubMed

Pediatric rhabdomyosarcoma cell lines are resistant to Fas-induced apoptosis and highly sensitive to TRAIL-induced apoptosis.

Petak I., Douglas L., Tillman D.M., Vernes R., Houghton J.A.

Clin. Cancer Res. 6:4119-4127(2000).

PubMed

Web Resources

cccells.org cccells.org pptpinvitro.org