SCLC-22HHomo sapiens (Human)Cancer cell line

Also known as: SCLC22H

🤖 AI SummaryBased on 7 publications

Quick Overview

Human small cell lung cancer cell line with known genetic and molecular characteristics.

Detailed Summary

SCLC-22H is a human small cell lung cancer cell line derived from a pleural effusion. It is characterized by the expression of neuroendocrine markers such as L-DOPA decarboxylase (DDC), neuron-specific enolase (NSE), and creatine kinase (CK), including its BB isoenzyme. The cell line exhibits high levels of DDC activity and CK-BB, which are indicative of its neuroendocrine differentiation. SCLC-22H has been used in studies investigating the biological properties of small cell lung cancer, including its growth characteristics, response to therapies, and chromosomal abnormalities. It is also noted for its ability to form colonies in soft agar, indicating its tumorigenic potential. The cell line has been shown to have a near-diploid DNA content and specific chromosomal deletions, such as those involving chromosome 3p, which are common in small cell lung cancer. Additionally, SCLC-22H has been utilized in research related to the expression of galectins and viral sequences, contributing to the understanding of cancer immunology and tumor biology.

Research Applications

Neuroendocrine marker expression analysisGenomic and chromosomal characterizationDrug sensitivity and resistance studiesTumor biology and metastasis researchImmunological studies of cancer cell lines

Key Characteristics

Expression of DDC, NSE, and CK-BBNear-diploid DNA contentChromosomal deletions on 3pAbility to form colonies in soft agarHigh DDC activity and CK-BB levels

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2186
Species	Homo sapiens (Human)
Tissue Source	Pericardial effusion[UBERON:UBERON_0002409]

Donor Information

Age	46
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Small cell lung cancer
Lineage	Lung
Subtype	Small Cell Lung Cancer
OncoTree Code	SCLC

DepMap Information

Source Type	DSMZ
Source ID	ACH-001386_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Pro278Arg (c.833C>G)	Homozygous	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

D16S539

D18S51

14,15

D19S433

13,14

D21S11

29,31.2

D2S1338

17,20

D3S1358

D5S818

11,12

D7S820

D8S1179

12,13

FGA

Penta D

Penta E

12,13

TH01

9.3

TPOX

8,9

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

DOI PubMed PMC

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.

Wolf E., Gabius H.-J.

J. Cancer Res. Clin. Oncol. 127:375-386(2001).

DOI PubMed

Establishment, growth properties, and morphological characteristics of permanent human small cell lung cancer cell lines.

Bepler G., Jaques G., Neumann K., Aumuller G., Gropp C., Havemann K.

J. Cancer Res. Clin. Oncol. 113:31-40(1987).

DOI PubMed

Spontaneous changes in intermediate filament protein expression patterns in lung cancer cell lines.

Carney D.N., Vooijs G.P., Ramaekers F.C.S.

J. Cell Sci. 91:91-108(1988).

DOI PubMed

Markers and characteristics of human SCLC cell lines. Neuroendocrine markers, classical tumor markers, and chromosomal characteristics of permanent human small cell lung cancer cell lines.

Bepler G., Jaques G., Koehler A., Gropp C., Havemann K.

J. Cancer Res. Clin. Oncol. 113:253-259(1987).

DOI PubMed

Novel antigens characteristic of neuroendocrine malignancies.";

Boerman O.C., Ramaekers F.C.S.

Cancer 67:619-633(1991).

DOI PubMed

Expression of the vasopressin and gastrin-releasing peptide genes in small cell lung carcinoma cell lines.

Burbach J.P.H.

Pathobiology 60:136-142(1992).

DOI PubMed