SHI-1Homo sapiens (Human)Cancer cell line
Also known as: SHI1, shi-1
🤖 AI Summary0
Quick Overview
Human cell line with unknown tissue and disease origins.
Detailed Summary
The SHI-1 cell line is derived from Homo sapiens. However, detailed information regarding its tissue origin, disease association, and specific cell type remains unknown. As a human cell line, it may be utilized in various biological and medical research applications, though specific research applications are not explicitly detailed in the available data. Further studies are required to determine its characteristics and potential uses in scientific research.
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2191 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone marrow[UBERON:UBERON_0002371] |
Donor Information
| Age | 37 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Acute monoblastic/monocytic leukemia |
|---|---|
| Lineage | Myeloid |
| Subtype | Acute Monoblastic/Monocytic Leukemia |
| OncoTree Code | AMOL |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001647_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Ile195Thr (c.584T>C) | Unspecified | - | PubMed=12894234 |
| MutationSimple | KRAS | p.Gln61His (c.183A>C) | Heterozygous | 1 of 3 alleles | Unknown, PubMed=8426738 |
| Gene fusion | AFDN | KMT2A-AFDN, MLL-MLLT4, MLL-AF6 | - | - | PubMed=15951289, PubMed=15921626 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,12
D13S317
9
D16S539
9,10
D18S51
13
D19S433
15,17
D21S11
30,30.2
D2S1338
20,25
D3S1358
16,17
D5S818
12,13
D7S820
11,12
D8S1179
13,14
FGA
21,24
Penta D
9,10
Penta E
11,14
TH01
6,7
TPOX
8,9
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
A new human acute monocytic leukemia cell line SHI-1 with t(6;11)(q27;q23), p53 gene alterations and high tumorigenicity in nude mice.
Ceng J.-N.
Haematologica 90:766-775(2005).